Application of Small Organic Molecules Reveals Cooperative TGFβ and BMP Regulation of Mesothelial Cell Behaviors

Epicardial development is a process during which epithelial sheet movement, single cell migration, and differentiation are coordinated to generate coronary arteries. Signaling cascades regulate the concurrent and complex nature of these three events. Through simple and highly reproducible assays, we...

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Veröffentlicht in:	ACS chemical biology 2011-09, Vol.6 (9), p.952-961
Hauptverfasser:	Cross, Emily E, Thomason, Rebecca T, Martinez, Mitchell, Hopkins, Corey R, Hong, Charles C, Bader, David M
Format:	Artikel
Sprache:	eng
Schlagworte:	Bone Morphogenetic Proteins - antagonists & inhibitors Bone Morphogenetic Proteins - metabolism Cell Differentiation - drug effects Cell Movement - drug effects Cells, Cultured Epithelial Cells - cytology Epithelial Cells - drug effects Humans Molecular Structure Molecular Weight Pyrazoles - chemistry Pyrazoles - pharmacology Pyrimidines - chemistry Pyrimidines - pharmacology Signal Transduction - drug effects Stereoisomerism Structure-Activity Relationship Transforming Growth Factor beta - metabolism
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