A Small-Molecule Screening Strategy To Identify Suppressors of Statin Myopathy

The reduction of plasma low-density lipoprotein levels by HMG-CoA reductase inhibitors, or statins, has had a revolutionary impact in medicine, but muscle-related side effects remain a dose-limiting toxicity in many patients. We describe a chemical epistasis approach that can be useful in refining t...

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Veröffentlicht in:	ACS chemical biology 2011-09, Vol.6 (9), p.900-904
Hauptverfasser:	Wagner, Bridget K, Gilbert, Tamara J, Hanai, Jun-ichi, Imamura, Shintaro, Bodycombe, Nicole E, Bon, Robin S, Waldmann, Herbert, Clemons, Paul A, Sukhatme, Vikas P, Mootha, Vamsi K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carbazoles - pharmacology Cell Line High-Throughput Screening Assays - methods Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects Molecular Structure Molecular Weight Muscle Fibers, Skeletal - drug effects Muscle Fibers, Skeletal - pathology Muscular Diseases - chemically induced Muscular Diseases - pathology Muscular Diseases - prevention & control Zebrafish
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