Determinants of Successful CD8+ T-Cell Adoptive Immunotherapy for Large Established Tumors in Mice

Adoptive cell transfer (ACT) of tumor infiltrating or genetically engineered T cells can cause durable responses in patients with metastatic cancer. Multiple clinically modifiable parameters can comprise this therapy, including cell dose and phenotype, in vivo antigen restimulation, and common gamma...

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Veröffentlicht in:	Clinical cancer research 2011-08, Vol.17 (16), p.5343-5352
Hauptverfasser:	KLEBANOFF, Christopher A, GATTINONI, Luca, ROSENBERG, Steven A, RESTIFO, Nicholas P, PALMER, Douglas C, MURANSKI, Pawel, YUN JI, HINRICHS, Christian S, BORMAN, Zachary A, KERKAR, Sid P, SCOTT, Christopher D, FINKELSTEIN, Steven E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Cancer Vaccines - administration & dosage Cancer Vaccines - immunology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - transplantation Cell Differentiation - immunology Cell Line, Tumor Cytokines - immunology Cytokines - therapeutic use Dose-Response Relationship, Drug Immunologic Memory - immunology Immunotherapy, Adoptive - methods Interleukin-15 - immunology Interleukin-15 - pharmacology Interleukin-2 - immunology Interleukin-2 - pharmacology Interleukin-7 - immunology Interleukin-7 - pharmacology Interleukins - immunology Interleukins - pharmacology Medical sciences Melanoma, Experimental - immunology Melanoma, Experimental - pathology Melanoma, Experimental - therapy Mice Mice, Inbred C57BL Mice, Transgenic Pharmacology. Drug treatments Regression Analysis Treatment Outcome Tumor Burden - drug effects Tumor Burden - immunology
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