TNF-α-converting enzyme/a disintegrin and metalloprotease-17 mediates mechanotransduction in murine tracheal epithelial cells

Bronchoconstriction applies compressive stress to airway epithelial cells. We show that the application of compressive stress to cultured murine tracheal epithelial cells elicits the increased phosphorylation of extracellular signal-regulated kinase (ERK) and Akt through an epidermal growth factor r...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2011-08, Vol.45 (2), p.376-385
Hauptverfasser:	Shiomi, Tetsuya, Tschumperlin, Daniel J, Park, Jin-Ah, Sunnarborg, Susan W, Horiuchi, Keisuke, Blobel, Carl P, Drazen, Jeffrey M
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM Proteins - physiology ADAM17 Protein Animals Cells, Cultured Epithelial Cells - metabolism Extracellular Signal-Regulated MAP Kinases - metabolism Female Heparin-binding EGF-like Growth Factor Immunoblotting Integrases - metabolism Intercellular Signaling Peptides and Proteins - physiology Male Mechanotransduction, Cellular - physiology Mice Mice, Inbred C57BL Mice, Knockout Phosphorylation Proto-Oncogene Proteins c-akt - metabolism Receptor, Epidermal Growth Factor - metabolism Signal Transduction Stress, Mechanical Trachea - cytology Trachea - metabolism Tumor Necrosis Factor-alpha - physiology
Online-Zugang:	Volltext
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