Influence of genetic, biological and pharmacological factors on warfarin dose in a Southern Brazilian population of European ancestry

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Warfarin is an oral anticoagulant widely used for thromboembolic disease prophylaxis. The pharmacokinetics and pharmacodynamics of this drug vary with environmental and genetic factors. Several algorithms including genetic and non‐genetic factors have been...

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Veröffentlicht in:	British journal of clinical pharmacology 2011-09, Vol.72 (3), p.442-450
Hauptverfasser:	Botton, Mariana Rodrigues, Bandinelli, Eliane, Rohde, Luis Eduardo Paim, Amon, Luis Carlos, Hutz, Mara Helena
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Algorithms Anticoagulants - administration & dosage Aryl Hydrocarbon Hydroxylases - genetics Biological and medical sciences Brazil - epidemiology CYP2C9 CYP4F2 Cytochrome P-450 CYP2C9 Cytochrome P-450 Enzyme System - genetics Cytochrome P450 Family 4 Dose-Response Relationship, Drug Female Genotype Humans Male Medical sciences Middle Aged Mixed Function Oxygenases - genetics Pedigree Pharmacogenetics Pharmacology. Drug treatments Polymorphism, Single Nucleotide Statistics as Topic Vitamin K Epoxide Reductases VKORC1 warfarin Warfarin - administration & dosage White People - genetics
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