On-tissue chemical derivatization of 3-methoxysalicylamine for MALDI-imaging mass spectrometry

MALDI‐imaging mass spectrometry (IMS) has been shown to be a powerful tool to study drug distributions in organ tissue as well as whole animal bodies. Nevertheless, not all drugs are amenable to MALDI while others may be limited by poor sensitivity poor sensitivity. The use of chemical derivatizatio...

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Veröffentlicht in:	Journal of mass spectrometry. 2011-08, Vol.46 (8), p.840-846
Hauptverfasser:	Chacon, Almary, Zagol-Ikapitte, Irene, Amarnath, Venkataraman, Reyzer, Michelle L., Oates, John A., Caprioli, Richard M., Boutaud, Olivier
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes - chemistry Aminosalicylic Acids - chemistry Animals Biological and medical sciences chemical derivatization Derivatives direct tissue Drugs General pharmacology Histocytological Preparation Techniques - methods imaging mass spectrometry Imidazoles - chemistry Investigative techniques, diagnostic techniques (general aspects) MALDI Male Mass spectrometry Medical sciences Mice Mice, Inbred C57BL Miscellaneous. Technology Molecular Imaging - methods Organs Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Reproducibility of Results Scavengers Sensitivity and Specificity small molecule Spatial distribution Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods
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