LUBAC regulates NF-κB activation upon genotoxic stress by promoting linear ubiquitination of NEMO

The transcription factor nuclear factor κB (NF‐κB) regulates various cellular processes such as inflammation and apoptosis. The NF‐κB essential modulator (NEMO/IKKγ) is indispensable for NF‐κB activation by diverse stimuli including genotoxic stress. Here, we show that NEMO linear ubiquitination on...

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Veröffentlicht in:	The EMBO journal 2011-09, Vol.30 (18), p.3741-3753
Hauptverfasser:	Niu, Jixiao, Shi, Yuling, Iwai, Kazuhiro, Wu, Zhao-Hui
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line DNA Damage EMBO31 EMBO37 genotoxic stress Humans I-kappa B Kinase - metabolism LUBAC NEMO NF-kappa B - biosynthesis NF-κB Ubiquitin-Protein Ligases - metabolism Ubiquitination
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