CD8+ CD28− and CD8+ CD57+ T cells and their role in health and disease

Summary Chronic antigenic stimulation leads to gradual accumulation of late‐differentiated, antigen‐specific, oligoclonal T cells, particularly within the CD8+ T‐cell compartment. They are characterized by critically shortened telomeres, loss of CD28 and/or gain of CD57 expression and are defined as...

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Veröffentlicht in:	Immunology 2011-09, Vol.134 (1), p.17-32
Hauptverfasser:	Strioga, Marius, Pasukoniene, Vita, Characiejus, Dainius
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CD28 Antigens - metabolism CD57 Antigens - metabolism CD8+ CD28− T cells CD8+ CD57+ T cells CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Humans Immune system immunosenescence Lymphocytes Population Review T cell receptors T-Lymphocyte Subsets - cytology T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism
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