PLZF induces an intravascular surveillance program mediated by long-lived LFA-1-ICAM-1 interactions
Innate-like NKT cells conspicuously accumulate within the liver microvasculature of healthy mice, crawling on the luminal side of endothelial cells, but their general recirculation pattern and the mechanism of their intravascular behavior have not been elucidated. Using parabiotic mice, we demonstra...
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| Veröffentlicht in: | The Journal of experimental medicine 2011-06, Vol.208 (6), p.1179-1188 |
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| container_title | The Journal of experimental medicine |
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| creator | Thomas, Seddon Y Scanlon, Seth T Griewank, Klaus G Constantinides, Michael G Savage, Adam K Barr, Kenneth A Meng, Fanyong Luster, Andrew D Bendelac, Albert |
| description | Innate-like NKT cells conspicuously accumulate within the liver microvasculature of healthy mice, crawling on the luminal side of endothelial cells, but their general recirculation pattern and the mechanism of their intravascular behavior have not been elucidated. Using parabiotic mice, we demonstrated that, despite their intravascular location, most liver NKT cells failed to recirculate. Antibody blocking experiments established that they were retained locally through constitutive LFA-1-intercellular adhesion molecule (ICAM) 1 interactions. This unprecedented lifelong intravascular residence could be induced in conventional CD4 T cells by the sole expression of promyelocytic leukemia zinc finger (PLZF), a transcription factor specifically expressed in the NKT lineage. These findings reveal the unique genetic and biochemical pathway that underlies the innate intravascular surveillance program of NKT cells. |
| doi_str_mv | 10.1084/jem.20102630 |
| format | Article |
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Using parabiotic mice, we demonstrated that, despite their intravascular location, most liver NKT cells failed to recirculate. Antibody blocking experiments established that they were retained locally through constitutive LFA-1-intercellular adhesion molecule (ICAM) 1 interactions. This unprecedented lifelong intravascular residence could be induced in conventional CD4 T cells by the sole expression of promyelocytic leukemia zinc finger (PLZF), a transcription factor specifically expressed in the NKT lineage. These findings reveal the unique genetic and biochemical pathway that underlies the innate intravascular surveillance program of NKT cells.</description><identifier>ISSN: 0022-1007</identifier><identifier>EISSN: 1540-9538</identifier><identifier>DOI: 10.1084/jem.20102630</identifier><identifier>PMID: 21624939</identifier><language>eng</language><publisher>United States: The Rockefeller University Press</publisher><subject>Animals ; CD4-Positive T-Lymphocytes - cytology ; Cell Adhesion ; Cell Lineage ; Flow Cytometry - methods ; Gene Expression Regulation ; Intercellular Adhesion Molecule-1 - metabolism ; Kruppel-Like Transcription Factors - metabolism ; Liver - blood supply ; Lymphocyte Function-Associated Antigen-1 - metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Microcirculation ; Microscopy, Fluorescence - methods ; Natural Killer T-Cells - metabolism ; Promyelocytic Leukemia Zinc Finger Protein</subject><ispartof>The Journal of experimental medicine, 2011-06, Vol.208 (6), p.1179-1188</ispartof><rights>2011 Thomas et al. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-74987cfe880b1f56777bb36fce570e77a3244e3df4d488441050823483c218423</citedby><cites>FETCH-LOGICAL-c481t-74987cfe880b1f56777bb36fce570e77a3244e3df4d488441050823483c218423</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21624939$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thomas, Seddon Y</creatorcontrib><creatorcontrib>Scanlon, Seth T</creatorcontrib><creatorcontrib>Griewank, Klaus G</creatorcontrib><creatorcontrib>Constantinides, Michael G</creatorcontrib><creatorcontrib>Savage, Adam K</creatorcontrib><creatorcontrib>Barr, Kenneth A</creatorcontrib><creatorcontrib>Meng, Fanyong</creatorcontrib><creatorcontrib>Luster, Andrew D</creatorcontrib><creatorcontrib>Bendelac, Albert</creatorcontrib><title>PLZF induces an intravascular surveillance program mediated by long-lived LFA-1-ICAM-1 interactions</title><title>The Journal of experimental medicine</title><addtitle>J Exp Med</addtitle><description>Innate-like NKT cells conspicuously accumulate within the liver microvasculature of healthy mice, crawling on the luminal side of endothelial cells, but their general recirculation pattern and the mechanism of their intravascular behavior have not been elucidated. 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These findings reveal the unique genetic and biochemical pathway that underlies the innate intravascular surveillance program of NKT cells.</description><subject>Animals</subject><subject>CD4-Positive T-Lymphocytes - cytology</subject><subject>Cell Adhesion</subject><subject>Cell Lineage</subject><subject>Flow Cytometry - methods</subject><subject>Gene Expression Regulation</subject><subject>Intercellular Adhesion Molecule-1 - metabolism</subject><subject>Kruppel-Like Transcription Factors - metabolism</subject><subject>Liver - blood supply</subject><subject>Lymphocyte Function-Associated Antigen-1 - metabolism</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Transgenic</subject><subject>Microcirculation</subject><subject>Microscopy, Fluorescence - methods</subject><subject>Natural Killer T-Cells - metabolism</subject><subject>Promyelocytic Leukemia Zinc Finger Protein</subject><issn>0022-1007</issn><issn>1540-9538</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkT1rHDEQhkVwiC92utRhOzeWM5JmV9rGYIwvCVxIirhJI7Ta2YvMflyk3QP_e-vwB3GVShJ6eJh3XsY-CrgQYPDzHQ0XEgTISsEbthIlAq9LZY7YCkBKLgD0MXuf0h2AQCyrd-xYikpireoV8z83v9dFGNvFUyrcmK9zdHuX_NK7WKQl7in0vRs9Fbs4baMbioHa4GZqi-a-6Kdxy_uwz6_N-ooL_u366jsXBw1F5-cwjemUve1cn-jD03nCbtc3v66_8s2PLxnfcI9GzFxjbbTvyBhoRFdWWuumUVXnqdRAWjslEUm1HbZoDKKAEoxUaJSXwqBUJ-zy0btbmjyjp0OU3u5iGFy8t5ML9vXPGP7Y7bS3Sujs1llw9iSI09-F0myHkDwd4tO0JFsDoq7rSv6XNDqvHatKZPL8kfRxSilS9zKPAHso0OYC7XOBGf_0b4YX-Lkx9QCFU5W6</recordid><startdate>20110606</startdate><enddate>20110606</enddate><creator>Thomas, Seddon Y</creator><creator>Scanlon, Seth T</creator><creator>Griewank, Klaus G</creator><creator>Constantinides, Michael G</creator><creator>Savage, Adam K</creator><creator>Barr, Kenneth A</creator><creator>Meng, Fanyong</creator><creator>Luster, Andrew D</creator><creator>Bendelac, Albert</creator><general>The Rockefeller University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20110606</creationdate><title>PLZF induces an intravascular surveillance program mediated by long-lived LFA-1-ICAM-1 interactions</title><author>Thomas, Seddon Y ; Scanlon, Seth T ; Griewank, Klaus G ; Constantinides, Michael G ; Savage, Adam K ; Barr, Kenneth A ; Meng, Fanyong ; Luster, Andrew D ; Bendelac, Albert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-74987cfe880b1f56777bb36fce570e77a3244e3df4d488441050823483c218423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>CD4-Positive T-Lymphocytes - cytology</topic><topic>Cell Adhesion</topic><topic>Cell Lineage</topic><topic>Flow Cytometry - methods</topic><topic>Gene Expression Regulation</topic><topic>Intercellular Adhesion Molecule-1 - metabolism</topic><topic>Kruppel-Like Transcription Factors - metabolism</topic><topic>Liver - blood supply</topic><topic>Lymphocyte Function-Associated Antigen-1 - metabolism</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Transgenic</topic><topic>Microcirculation</topic><topic>Microscopy, Fluorescence - methods</topic><topic>Natural Killer T-Cells - metabolism</topic><topic>Promyelocytic Leukemia Zinc Finger Protein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thomas, Seddon Y</creatorcontrib><creatorcontrib>Scanlon, Seth T</creatorcontrib><creatorcontrib>Griewank, Klaus G</creatorcontrib><creatorcontrib>Constantinides, Michael G</creatorcontrib><creatorcontrib>Savage, Adam K</creatorcontrib><creatorcontrib>Barr, Kenneth A</creatorcontrib><creatorcontrib>Meng, Fanyong</creatorcontrib><creatorcontrib>Luster, Andrew D</creatorcontrib><creatorcontrib>Bendelac, Albert</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of experimental medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thomas, Seddon Y</au><au>Scanlon, Seth T</au><au>Griewank, Klaus G</au><au>Constantinides, Michael G</au><au>Savage, Adam K</au><au>Barr, Kenneth A</au><au>Meng, Fanyong</au><au>Luster, Andrew D</au><au>Bendelac, Albert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PLZF induces an intravascular surveillance program mediated by long-lived LFA-1-ICAM-1 interactions</atitle><jtitle>The Journal of experimental medicine</jtitle><addtitle>J Exp Med</addtitle><date>2011-06-06</date><risdate>2011</risdate><volume>208</volume><issue>6</issue><spage>1179</spage><epage>1188</epage><pages>1179-1188</pages><issn>0022-1007</issn><eissn>1540-9538</eissn><abstract>Innate-like NKT cells conspicuously accumulate within the liver microvasculature of healthy mice, crawling on the luminal side of endothelial cells, but their general recirculation pattern and the mechanism of their intravascular behavior have not been elucidated. 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| subjects | Animals CD4-Positive T-Lymphocytes - cytology Cell Adhesion Cell Lineage Flow Cytometry - methods Gene Expression Regulation Intercellular Adhesion Molecule-1 - metabolism Kruppel-Like Transcription Factors - metabolism Liver - blood supply Lymphocyte Function-Associated Antigen-1 - metabolism Mice Mice, Inbred C57BL Mice, Transgenic Microcirculation Microscopy, Fluorescence - methods Natural Killer T-Cells - metabolism Promyelocytic Leukemia Zinc Finger Protein |
| title | PLZF induces an intravascular surveillance program mediated by long-lived LFA-1-ICAM-1 interactions |
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