Structural Analysis of Human FANCL, the E3 Ligase in the Fanconi Anemia Pathway

The Fanconi anemia (FA) pathway is essential for the repair of DNA interstrand cross-links. At the heart of this pathway is the monoubiquitination of the FANCI-FANCD2 (ID) complex by the multiprotein “core complex” containing the E3 ubiquitin ligase FANCL. Vertebrate organisms have the eight-protein...

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Veröffentlicht in:	The Journal of biological chemistry 2011-09, Vol.286 (37), p.32628-32637
Hauptverfasser:	Hodson, Charlotte, Cole, Ambrose R., Lewis, Laurence P.C., Miles, Jennifer A., Purkiss, Andrew, Walden, Helen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Crystal Structure Crystallography DNA Damage Drosophila melanogaster E3 Ubiquitin Ligase Fanconi Anemia - enzymology Fanconi Anemia - genetics Fanconi Anemia Complementation Group D2 Protein - chemistry Fanconi Anemia Complementation Group D2 Protein - genetics Fanconi Anemia Complementation Group D2 Protein - metabolism Fanconi Anemia Complementation Group L Protein - chemistry Fanconi Anemia Complementation Group L Protein - genetics Fanconi Anemia Complementation Group L Protein - metabolism Humans Mutation Peptide Mapping Protein Binding Protein Folding Protein Structure Protein Structure and Folding Protein Structure, Quaternary Protein Structure, Tertiary Ubiquitin-Conjugating Enzymes - chemistry Ubiquitin-Conjugating Enzymes - genetics Ubiquitin-Conjugating Enzymes - metabolism
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