Interaction between the Human Mitochondrial Import Receptors Tom20 and Tom70 in Vitro Suggests a Chaperone Displacement Mechanism

The mitochondrial import receptor Tom70 contains a tetratricopeptide repeat (TPR) clamp domain, which allows the receptor to interact with the molecular chaperones, Hsc70/Hsp70 and Hsp90. Preprotein recognition by Tom70, a critical step to initiate import, is dependent on these cytosolic chaperones....

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Veröffentlicht in:	The Journal of biological chemistry 2011-09, Vol.286 (37), p.32208-32219
Hauptverfasser:	Fan, Anna C.Y., Kozlov, Guennadi, Hoegl, Annabelle, Marcellus, Richard C., Wong, Michael J.H., Gehring, Kalle, Young, Jason C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Biophysics Chaperone Chaperonin Heat Shock Protein Heat-Shock Proteins - chemistry Heat-Shock Proteins - genetics Heat-Shock Proteins - metabolism HeLa Cells Humans Membrane Transport Proteins - chemistry Membrane Transport Proteins - genetics Membrane Transport Proteins - metabolism Mitochondria Mitochondrial Membrane Transport Proteins - chemistry Mitochondrial Membrane Transport Proteins - genetics Mitochondrial Membrane Transport Proteins - metabolism Mitochondrial Membranes - chemistry Mitochondrial Membranes - metabolism Mutation Nuclear Magnetic Resonance, Biomolecular Peptides - pharmacology Protein Binding - drug effects Protein Binding - physiology Protein Complexes Protein Precursors - chemistry Protein Precursors - genetics Protein Precursors - metabolism Protein Structure and Folding Protein Structure, Tertiary Protein Targeting Protein Transport - drug effects Protein Transport - physiology Receptors, Cell Surface - chemistry Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Surface Plasmon Resonance
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