Uptake of dietary retinoids at the maternal-fetal barrier: in vivo evidence for the role of lipoprotein lipase and alternative pathways

Dietary retinoids (vitamin A and its derivatives) contribute to normal embryonic development. However, the mechanism(s) involved in the transfer of recently ingested vitamin A from mother to embryo is not fully understood. We investigated in vivo whether lipoprotein lipase (LPL) facilitates the plac...

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Veröffentlicht in:	The Journal of biological chemistry 2011-09, Vol.286 (37), p.32198-32207
Hauptverfasser:	Wassef, Lesley, Quadro, Loredana
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chylomicrons - genetics Chylomicrons - metabolism Dietary Supplements Embryo, Mammalian - enzymology Female Gene Expression Regulation, Enzymologic - drug effects Gene Expression Regulation, Enzymologic - genetics Lipids Lipoprotein Lipase - biosynthesis Lipoprotein Lipase - genetics Maternal-Fetal Exchange - physiology Mice Mice, Knockout Placenta - enzymology Pregnancy - physiology Pregnancy Proteins - biosynthesis Receptors, LDL - genetics Receptors, LDL - metabolism Retinol-Binding Proteins - genetics Retinol-Binding Proteins - metabolism Vitamin A - pharmacokinetics Vitamin A - pharmacology Vitamins - pharmacokinetics Vitamins - pharmacology
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