Membrane-type Matrix Metalloproteinase-3 Regulates Neuronal Responsiveness to Myelin through Nogo-66 Receptor 1 Cleavage

Nogo-66 receptor 1 (NgR1) is a glycosylphosphatidylinositol-anchored receptor for myelin-associated inhibitors that restricts plasticity and axonal regrowth in the CNS. NgR1 is cleaved from the cell surface of SH-SY5Y neuroblastoma cells in a metalloproteinase-dependent manner; however, the mechanis...

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Veröffentlicht in:	The Journal of biological chemistry 2011-09, Vol.286 (36), p.31418-31424
Hauptverfasser:	Ferraro, Gino B., Morrison, Charlotte J., Overall, Christopher M., Strittmatter, Stephen M., Fournier, Alyson E.
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM ADAMTS Animals Axon Cells, Cultured GPI-Linked Proteins - analysis GPI-Linked Proteins - metabolism Humans Hydrolysis Matrix Metalloproteinase (MMP) Matrix Metalloproteinase 16 - physiology Mice Myelin Proteins - analysis Myelin Proteins - metabolism Myelin Sheath Neurobiology Neurodegeneration Neurological Diseases Neurons Neurons - cytology Neurons - physiology Neuroscience Nogo Receptor 1 Peptide Fragments - analysis Rats Receptors, Cell Surface - analysis Receptors, Cell Surface - metabolism Shedding
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