Use of biotin targeted methotrexate-human serum albumin conjugated nanoparticles to enhance methotrexate antitumor efficacy

Biotin molecules could be used as suitable targeting moieties in targeted drug delivery systems against tumors. To develop a biotin targeted drug delivery system, we employed human serum albumin (HSA) as a carrier. Methotrexate (MTX) molecules were conjugated to HSA. MTX-HSA nanoparticles (MTX-HSA N...

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Veröffentlicht in:	International journal of nanomedicine 2011-01, Vol.6, p.1863-1874
Hauptverfasser:	Taheri, Azade, Dinarvand, Rassoul, Nouri, Faranak Salman, Khorramizadeh, Mohammad Reza, Borougeni, Atefeh Taheri, Mansoori, Pooria, Atyabi, Fatemeh
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - administration & dosage biotin Biotin - administration & dosage Cell Line, Tumor conjugates Drug Delivery Systems Female human serum albumin Humans in vivo anticancer delivery Mammary Neoplasms, Experimental - drug therapy methotrexate Methotrexate - administration & dosage Mice Mice, Inbred BALB C Nanoconjugates - administration & dosage Nanomedicine Original Research Serum Albumin - administration & dosage targeted drug delivery
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