Molecular interactions between Vestigial and Scalloped promote wing formation in Drosophila

Scalloped (Sd) and Vestigial (Vg) are each needed for Drosophila wing development. We show that Sd is required for Vg function and that altering their relative cellular levels inhibits wing formation. In vitro, Vg binds directly to both Sd and its human homolog, Transcription Enhancer Factor-1. The...

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Veröffentlicht in:	Genes & development 1998-12, Vol.12 (24), p.3815-3820
Hauptverfasser:	Simmonds, A J, Liu, X, Soanes, K H, Krause, H M, Irvine, K D, Bell, J B
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Binding Sites Body Patterning Conserved Sequence Dimerization DNA-Binding Proteins - metabolism Drosophila Drosophila melanogaster - embryology Drosophila Proteins Gene Expression Regulation, Developmental Genes, Reporter - genetics Homeodomain Proteins - metabolism Humans Insect Proteins - chemistry Insect Proteins - genetics Insect Proteins - metabolism Molecular Sequence Data Nuclear Proteins - chemistry Nuclear Proteins - genetics Nuclear Proteins - metabolism Protein Binding Research Communication Sequence Deletion Transcription Factors - chemistry Transcription Factors - genetics Transcription Factors - metabolism Transcriptional Activation Wings, Animal - embryology Yeasts
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