Molecular interactions between Vestigial and Scalloped promote wing formation in Drosophila
Scalloped (Sd) and Vestigial (Vg) are each needed for Drosophila wing development. We show that Sd is required for Vg function and that altering their relative cellular levels inhibits wing formation. In vitro, Vg binds directly to both Sd and its human homolog, Transcription Enhancer Factor-1. The...
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| Veröffentlicht in: | Genes & development 1998-12, Vol.12 (24), p.3815-3820 |
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| creator | Simmonds, A J Liu, X Soanes, K H Krause, H M Irvine, K D Bell, J B |
| description | Scalloped (Sd) and Vestigial (Vg) are each needed for Drosophila wing development. We show that Sd is required for Vg function and that altering their relative cellular levels inhibits wing formation. In vitro, Vg binds directly to both Sd and its human homolog, Transcription Enhancer Factor-1. The interaction domains map to a small region of Vg that is essential for Vg-mediated gene activation and to the carboxy-terminal half of Sd. Our observations indicate that Vg and Sd function coordinately to control the expression of genes required for wing development, which implies that Vg is a tissue-specific transcriptional intermediary factor of Sd. |
| doi_str_mv | 10.1101/gad.12.24.3815 |
| format | Article |
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We show that Sd is required for Vg function and that altering their relative cellular levels inhibits wing formation. In vitro, Vg binds directly to both Sd and its human homolog, Transcription Enhancer Factor-1. The interaction domains map to a small region of Vg that is essential for Vg-mediated gene activation and to the carboxy-terminal half of Sd. 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Liu, X ; Soanes, K H ; Krause, H M ; Irvine, K D ; Bell, J B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-ae26e6fd2e3fc25a1346b93a118d4935b98165abfd2711bbf9a10d04fc3892513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Binding Sites</topic><topic>Body Patterning</topic><topic>Conserved Sequence</topic><topic>Dimerization</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Drosophila</topic><topic>Drosophila melanogaster - embryology</topic><topic>Drosophila Proteins</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Genes, Reporter - genetics</topic><topic>Homeodomain Proteins - metabolism</topic><topic>Humans</topic><topic>Insect Proteins - chemistry</topic><topic>Insect Proteins - genetics</topic><topic>Insect Proteins - metabolism</topic><topic>Molecular Sequence Data</topic><topic>Nuclear Proteins - chemistry</topic><topic>Nuclear Proteins - genetics</topic><topic>Nuclear Proteins - metabolism</topic><topic>Protein Binding</topic><topic>Research Communication</topic><topic>Sequence Deletion</topic><topic>Transcription Factors - chemistry</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><topic>Transcriptional Activation</topic><topic>Wings, Animal - embryology</topic><topic>Yeasts</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Simmonds, A J</creatorcontrib><creatorcontrib>Liu, X</creatorcontrib><creatorcontrib>Soanes, K H</creatorcontrib><creatorcontrib>Krause, H M</creatorcontrib><creatorcontrib>Irvine, K D</creatorcontrib><creatorcontrib>Bell, J B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Genes & development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Simmonds, A J</au><au>Liu, X</au><au>Soanes, K H</au><au>Krause, H M</au><au>Irvine, K D</au><au>Bell, J B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular interactions between Vestigial and Scalloped promote wing formation in Drosophila</atitle><jtitle>Genes & development</jtitle><addtitle>Genes Dev</addtitle><date>1998-12-15</date><risdate>1998</risdate><volume>12</volume><issue>24</issue><spage>3815</spage><epage>3820</epage><pages>3815-3820</pages><issn>0890-9369</issn><eissn>1549-5477</eissn><abstract>Scalloped (Sd) and Vestigial (Vg) are each needed for Drosophila wing development. We show that Sd is required for Vg function and that altering their relative cellular levels inhibits wing formation. In vitro, Vg binds directly to both Sd and its human homolog, Transcription Enhancer Factor-1. The interaction domains map to a small region of Vg that is essential for Vg-mediated gene activation and to the carboxy-terminal half of Sd. Our observations indicate that Vg and Sd function coordinately to control the expression of genes required for wing development, which implies that Vg is a tissue-specific transcriptional intermediary factor of Sd.</abstract><cop>United States</cop><pub>Cold Spring Harbor Laboratory Press</pub><pmid>9869635</pmid><doi>10.1101/gad.12.24.3815</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Amino Acid Sequence Animals Binding Sites Body Patterning Conserved Sequence Dimerization DNA-Binding Proteins - metabolism Drosophila Drosophila melanogaster - embryology Drosophila Proteins Gene Expression Regulation, Developmental Genes, Reporter - genetics Homeodomain Proteins - metabolism Humans Insect Proteins - chemistry Insect Proteins - genetics Insect Proteins - metabolism Molecular Sequence Data Nuclear Proteins - chemistry Nuclear Proteins - genetics Nuclear Proteins - metabolism Protein Binding Research Communication Sequence Deletion Transcription Factors - chemistry Transcription Factors - genetics Transcription Factors - metabolism Transcriptional Activation Wings, Animal - embryology Yeasts |
| title | Molecular interactions between Vestigial and Scalloped promote wing formation in Drosophila |
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