A novel organelle, the piNG-body, in the nuage of Drosophila male germ cells is associated with piRNA-mediated gene silencing

Proteins of the PIWI subfamily Aub and AGO3 associated with the germline-specific perinuclear granules (nuage) are involved in the silencing of retrotransposons and other selfish repetitive elements in the Drosophila genome. PIWI proteins and their 25- to 30-nt PIWI-interacting RNA (piRNAs) are cons...

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Veröffentlicht in:	Molecular biology of the cell 2011-09, Vol.22 (18), p.3410-3419
Hauptverfasser:	Kibanov, Mikhail V, Egorova, Ksenia S, Ryazansky, Sergei S, Sokolova, Olesia A, Kotov, Alexei A, Olenkina, Oxana M, Stolyarenko, Anastasia D, Gvozdev, Vladimir A, Olenina, Ludmila V
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Animals Arginine Arginine - metabolism Argonaute Proteins - metabolism DEAD-box RNA Helicases - metabolism Derepression DNA methylation Drosophila Drosophila melanogaster - genetics Drosophila melanogaster - metabolism Drosophila Proteins - genetics Drosophila Proteins - metabolism Gene silencing Genes, Insect Genomes Germ cells Germ Cells - metabolism Granules Male Meiotic Prophase I Microscopy, Fluorescence miRNA Mutagenesis, Site-Directed Mutation Organelle Size Organelles Organelles - metabolism Peptide Initiation Factors - metabolism Protein Methyltransferases - genetics Protein Methyltransferases - metabolism Protein Processing, Post-Translational Protein Transport Retrotransposons RNA RNA Interference RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Spermatocytes Spermatogenesis Testes Testis - cytology Testis - metabolism Transcription
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