Collagen regulation of let-7 in pancreatic cancer involves TGF-β1-mediated membrane type 1-matrix metalloproteinase expression

Pancreatic ductal adenocarcinoma (PDAC) is associated with a pronounced collagen-rich fibrosis known as desmoplastic reaction; however, the role of fibrosis in PDAC is poorly understood. In this report we show that collagen can regulate the tumor suppressive let-7 family of microRNAs in pancreatic c...

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Veröffentlicht in:	Oncogene 2011-02, Vol.30 (8), p.1002-1008
Hauptverfasser:	Dangi-Garimella, S, Strouch, M J, Grippo, P J, Bentrem, D J, Munshi, H G
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/200 631/80/86 692/699/67/1504/1713 Adenocarcinoma Animals Apoptosis Biological and medical sciences Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - metabolism Carcinoma, Pancreatic Ductal - pathology Cell activation Cell Biology Cell culture Cell Line, Tumor Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Collagen Collagen (type I) Collagen Type I - metabolism Extracellular Matrix - metabolism Extracellular Matrix - pathology Fibrosis Fundamental and applied biological sciences. Psychology Gastroenterology. Liver. Pancreas. Abdomen Gels Gene Expression Gene Expression Regulation, Neoplastic - genetics Human Genetics Humans Immunoblotting Internal Medicine Liver. Biliary tract. Portal circulation. Exocrine pancreas Matrix metalloproteinase Matrix Metalloproteinase 14 - biosynthesis Medical sciences Medicine Medicine & Public Health Metalloproteinase Mice Mice, Nude MicroRNAs MicroRNAs - biosynthesis MicroRNAs - genetics miRNA Molecular and cellular biology Oncology Pancreatic cancer Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Reverse Transcriptase Polymerase Chain Reaction short-communication Signal Transduction - physiology Tissue culture Transforming Growth Factor beta1 - metabolism Transforming growth factor-b1 Tumors
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