Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway

RAD53 and MEC1 are essential genes required for the transcriptional and cell cycle responses to DNA damage and DNA replication blocks. We have examined the essential function of these genes and found that their lethality but not their checkpoint defects can be suppressed by increased expression of g...

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Veröffentlicht in:	Genes & development 1998-09, Vol.12 (18), p.2956-2970
Hauptverfasser:	Desany, B A, Alcasabas, A A, Bachant, J B, Elledge, S J
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Cycle Proteins Checkpoint Kinase 2 DNA Damage DNA Replication - genetics DNA, Fungal - biosynthesis Fungal Proteins - genetics Fungal Proteins - metabolism Gene Deletion Gene Expression Genes, Fungal Hydroxyurea - toxicity Intracellular Signaling Peptides and Proteins Mitosis - genetics Mitosis - physiology Point Mutation Protein Kinases - genetics Protein Kinases - metabolism Protein Serine-Threonine Kinases Research Paper Ribonucleotide Reductases - genetics Ribonucleotide Reductases - metabolism S Phase - genetics S Phase - physiology Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins Transcription, Genetic
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