Osa-containing Brahma chromatin remodeling complexes are required for the repression of wingless target genes
The Wingless signaling pathway directs many developmental processes in Drosophila by regulating the expression of specific downstream target genes. We report here that the product of the trithorax group gene osa is required to repress such genes in the absence of the Wingless signal. The Wingless-re...
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| Veröffentlicht in: | Genes & development 2000-12, Vol.14 (24), p.3140-3152 |
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| description | The Wingless signaling pathway directs many developmental processes in Drosophila by regulating the expression of specific downstream target genes. We report here that the product of the trithorax group gene osa is required to repress such genes in the absence of the Wingless signal. The Wingless-regulated genes nubbin, Distal-less, and decapentaplegic and a minimal enhancer from the Ultrabithorax gene are misexpressed in osa mutants and repressed by ectopic Osa. Osa-mediated repression occurs downstream of the up-regulation of Armadillo but is sensitive both to the relative levels of activating Armadillo/Pangolin and repressing Groucho/Pangolin complexes present and to the responsiveness of the promoter to Wingless. Osa functions as a component of the Brahma chromatin-remodeling complex; other components of this complex are likewise required to repress Wingless target genes. These results suggest that altering the conformation of chromatin is an important mechanism by which Wingless signaling activates gene expression. |
| doi_str_mv | 10.1101/gad.854300 |
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We report here that the product of the trithorax group gene osa is required to repress such genes in the absence of the Wingless signal. The Wingless-regulated genes nubbin, Distal-less, and decapentaplegic and a minimal enhancer from the Ultrabithorax gene are misexpressed in osa mutants and repressed by ectopic Osa. Osa-mediated repression occurs downstream of the up-regulation of Armadillo but is sensitive both to the relative levels of activating Armadillo/Pangolin and repressing Groucho/Pangolin complexes present and to the responsiveness of the promoter to Wingless. Osa functions as a component of the Brahma chromatin-remodeling complex; other components of this complex are likewise required to repress Wingless target genes. 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We report here that the product of the trithorax group gene osa is required to repress such genes in the absence of the Wingless signal. The Wingless-regulated genes nubbin, Distal-less, and decapentaplegic and a minimal enhancer from the Ultrabithorax gene are misexpressed in osa mutants and repressed by ectopic Osa. Osa-mediated repression occurs downstream of the up-regulation of Armadillo but is sensitive both to the relative levels of activating Armadillo/Pangolin and repressing Groucho/Pangolin complexes present and to the responsiveness of the promoter to Wingless. Osa functions as a component of the Brahma chromatin-remodeling complex; other components of this complex are likewise required to repress Wingless target genes. These results suggest that altering the conformation of chromatin is an important mechanism by which Wingless signaling activates gene expression.</description><subject>Animals</subject><subject>Armadillo Domain Proteins</subject><subject>Armadillo gene</subject><subject>armadillo protein</subject><subject>Basic Helix-Loop-Helix Transcription Factors</subject><subject>Cell Cycle Proteins</subject><subject>Chromatin - metabolism</subject><subject>Chromatin - ultrastructure</subject><subject>chromatin remodeling</subject><subject>Cytosol - metabolism</subject><subject>decapentaplegic gene</subject><subject>distal-less gene</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Drosophila</subject><subject>Drosophila - embryology</subject><subject>Drosophila - genetics</subject><subject>Drosophila Proteins</subject><subject>Embryo, Nonmammalian</subject><subject>Enhancer Elements, Genetic</subject><subject>Female</subject><subject>Gene Expression Regulation, Developmental</subject><subject>groucho protein</subject><subject>Histone Deacetylase 1</subject><subject>Histone Deacetylases</subject><subject>Homeodomain Proteins - genetics</subject><subject>Homeodomain Proteins - metabolism</subject><subject>Insect Proteins - genetics</subject><subject>Insect Proteins - metabolism</subject><subject>Male</subject><subject>Mutation</subject><subject>nubbin gene</subject><subject>osa gene</subject><subject>pangolin protein</subject><subject>POU Domain Factors</subject><subject>Proto-Oncogene Proteins - genetics</subject><subject>Proto-Oncogene Proteins - metabolism</subject><subject>Repressor Proteins - genetics</subject><subject>Repressor Proteins - metabolism</subject><subject>Research Paper</subject><subject>Trans-Activators - genetics</subject><subject>Trans-Activators - metabolism</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><subject>Ultrabithorax gene</subject><subject>Up-Regulation</subject><subject>wingless protein</subject><subject>Wnt1 Protein</subject><issn>0890-9369</issn><issn>1549-5477</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1P3DAQxS1UBFvg0j8A-dRDpYAdfx84AIK2EhKX9mxNkknWVWIvdrYf_32z2lVbTj2NZt7vjZ70CHnH2RXnjF8P0F1ZJQVjR2TFlXSVksa8IStmHauc0O6UvC3lG2NMM61PyCnnvJaW6RWZngtUbYozhBjiQO8yrCeg7TqnCeYQacYpdTjutDZNmxF_YqGQcRFetiFjR_uU6bzeHTYZSwkp0tTTH4tjXFY6Qx5wpgNGLOfkuIex4MVhnpGvjw9f7j9VT88fP9_fPlWtNGyuuDDOyqZltZbC9T32rpGoQdaA1tZc6F4bAIWq1h0CGMONE41VtUDlTCPOyM3-72bbTNi1GOcMo9_kMEH-5RME_1qJYe2H9N0LbrjUi__9wZ_TyxbL7KdQWhxHiJi2xZtaGmGt-C_IjVFK63oBP-zBNqdSMvZ_wnDmdy36pUW_b3GBL_-N_xc91CZ-A42LmvI</recordid><startdate>20001215</startdate><enddate>20001215</enddate><creator>Collins, R T</creator><creator>Treisman, J E</creator><general>Cold Spring Harbor Laboratory Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20001215</creationdate><title>Osa-containing Brahma chromatin remodeling complexes are required for the repression of wingless target genes</title><author>Collins, R T ; Treisman, J E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-137984bc026439ffef9b4e6a42ae882136f67aa5e526deaa771793b8523e597b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Armadillo Domain Proteins</topic><topic>Armadillo gene</topic><topic>armadillo protein</topic><topic>Basic Helix-Loop-Helix Transcription Factors</topic><topic>Cell Cycle Proteins</topic><topic>Chromatin - metabolism</topic><topic>Chromatin - ultrastructure</topic><topic>chromatin remodeling</topic><topic>Cytosol - metabolism</topic><topic>decapentaplegic gene</topic><topic>distal-less gene</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Drosophila</topic><topic>Drosophila - embryology</topic><topic>Drosophila - genetics</topic><topic>Drosophila Proteins</topic><topic>Embryo, Nonmammalian</topic><topic>Enhancer Elements, Genetic</topic><topic>Female</topic><topic>Gene Expression Regulation, Developmental</topic><topic>groucho protein</topic><topic>Histone Deacetylase 1</topic><topic>Histone Deacetylases</topic><topic>Homeodomain Proteins - genetics</topic><topic>Homeodomain Proteins - metabolism</topic><topic>Insect Proteins - genetics</topic><topic>Insect Proteins - metabolism</topic><topic>Male</topic><topic>Mutation</topic><topic>nubbin gene</topic><topic>osa gene</topic><topic>pangolin protein</topic><topic>POU Domain Factors</topic><topic>Proto-Oncogene Proteins - genetics</topic><topic>Proto-Oncogene Proteins - metabolism</topic><topic>Repressor Proteins - genetics</topic><topic>Repressor Proteins - metabolism</topic><topic>Research Paper</topic><topic>Trans-Activators - genetics</topic><topic>Trans-Activators - metabolism</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><topic>Ultrabithorax gene</topic><topic>Up-Regulation</topic><topic>wingless protein</topic><topic>Wnt1 Protein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Collins, R T</creatorcontrib><creatorcontrib>Treisman, J E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Genes & development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Collins, R T</au><au>Treisman, J E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Osa-containing Brahma chromatin remodeling complexes are required for the repression of wingless target genes</atitle><jtitle>Genes & development</jtitle><addtitle>Genes Dev</addtitle><date>2000-12-15</date><risdate>2000</risdate><volume>14</volume><issue>24</issue><spage>3140</spage><epage>3152</epage><pages>3140-3152</pages><issn>0890-9369</issn><eissn>1549-5477</eissn><abstract>The Wingless signaling pathway directs many developmental processes in Drosophila by regulating the expression of specific downstream target genes. We report here that the product of the trithorax group gene osa is required to repress such genes in the absence of the Wingless signal. The Wingless-regulated genes nubbin, Distal-less, and decapentaplegic and a minimal enhancer from the Ultrabithorax gene are misexpressed in osa mutants and repressed by ectopic Osa. Osa-mediated repression occurs downstream of the up-regulation of Armadillo but is sensitive both to the relative levels of activating Armadillo/Pangolin and repressing Groucho/Pangolin complexes present and to the responsiveness of the promoter to Wingless. Osa functions as a component of the Brahma chromatin-remodeling complex; other components of this complex are likewise required to repress Wingless target genes. These results suggest that altering the conformation of chromatin is an important mechanism by which Wingless signaling activates gene expression.</abstract><cop>United States</cop><pub>Cold Spring Harbor Laboratory Press</pub><pmid>11124806</pmid><doi>10.1101/gad.854300</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Armadillo Domain Proteins Armadillo gene armadillo protein Basic Helix-Loop-Helix Transcription Factors Cell Cycle Proteins Chromatin - metabolism Chromatin - ultrastructure chromatin remodeling Cytosol - metabolism decapentaplegic gene distal-less gene DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Drosophila Drosophila - embryology Drosophila - genetics Drosophila Proteins Embryo, Nonmammalian Enhancer Elements, Genetic Female Gene Expression Regulation, Developmental groucho protein Histone Deacetylase 1 Histone Deacetylases Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Insect Proteins - genetics Insect Proteins - metabolism Male Mutation nubbin gene osa gene pangolin protein POU Domain Factors Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Repressor Proteins - genetics Repressor Proteins - metabolism Research Paper Trans-Activators - genetics Trans-Activators - metabolism Transcription Factors - genetics Transcription Factors - metabolism Ultrabithorax gene Up-Regulation wingless protein Wnt1 Protein |
| title | Osa-containing Brahma chromatin remodeling complexes are required for the repression of wingless target genes |
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