Environmental cues, dendritic cells and the programming of tissue-selective lymphocyte trafficking
Lymphocytes are imprinted during activation with trafficking programs (combinations of adhesion and chemoattractant receptors) that target their migration to specific tissues and microenvironments. Cytokines contribute, but, for gut and skin, evolution has cleverly adapted external cues from food (v...
Gespeichert in:
| Veröffentlicht in: | Nature immunology 2008-09, Vol.9 (9), p.981-987 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 987 |
|---|---|
| container_issue | 9 |
| container_start_page | 981 |
| container_title | Nature immunology |
| container_volume | 9 |
| creator | Butcher, Eugene C Sigmundsdottir, Hekla |
| description | Lymphocytes are imprinted during activation with trafficking programs (combinations of adhesion and chemoattractant receptors) that target their migration to specific tissues and microenvironments. Cytokines contribute, but, for gut and skin, evolution has cleverly adapted external cues from food (vitamin A) and sunlight (ultraviolet-induced vitamin D3) to imprint lymphocyte homing to the small intestines and T cell migration into the epidermis. Dendritic cells are essential: they process the vitamins to their active metabolites (retinoic acid and 1,25(OH)
2
D3) for presentation with antigen to lymphocytes, and they help export environmental cues through lymphatics to draining lymph nodes, to program the trafficking and effector functions of naive T and B cells. |
| doi_str_mv | 10.1038/ni.f.208 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3171274</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A190332439</galeid><sourcerecordid>A190332439</sourcerecordid><originalsourceid>FETCH-LOGICAL-c618t-fb26bc8bc14f3e30e08959d2a906c12f249592b5ecc50722433b051a51bd6f2a3</originalsourceid><addsrcrecordid>eNqFkmuLEzEUhgdR3LUK_gIZFLyArTlJ5vZFWJZVFxYEL59DJnMyzTqT1CRT7L83paW14oV8yOU85w3nPSfLHgNZAGH1G2sWekFJfSc7h4I2c9pAefdwJvVZ9iCEW0KAVyW_n51BXQFwVpxn7ZVdG-_siDbKIVcThtd5h7bzJhqVKxyGkEvb5XGJ-cq73stxNLbPnc6jCWHCecABVTRrzIfNuFo6tYmYRy-1NupbQh9m97QcAj7a77Ps67urL5cf5jcf319fXtzMVQl1nOuWlq2qWwVcM2QESd0UTUdlQ0oFVFOerrQtUKmCVJRyxlpSgCyg7UpNJZtlb3e6q6kdsVOpIi8HsfJmlH4jnDTiNGLNUvRuLRhUQCueBF7sBbz7noyIYjRh64C06KYg6gJ4CQy25PN_kmXDOWnI_0FKmopWqYez7Olv4K2bvE1-CUppxSpSQYKe7aBeDiiM1S7VobaK4gIawlgypUnU4g9UWh2ORjmL2qT3k4RXJwmJifgj9nIKQVx__nTKvtyxyrsQPOqDv0DEdhaTq0KnuuqEPvm1H0dwP3zHf0MK2R79sea_i1kZJ48HsQPwEz3y8ZE</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>222737071</pqid></control><display><type>article</type><title>Environmental cues, dendritic cells and the programming of tissue-selective lymphocyte trafficking</title><source>MEDLINE</source><source>Nature Journals Online</source><source>Alma/SFX Local Collection</source><creator>Butcher, Eugene C ; Sigmundsdottir, Hekla</creator><creatorcontrib>Butcher, Eugene C ; Sigmundsdottir, Hekla</creatorcontrib><description>Lymphocytes are imprinted during activation with trafficking programs (combinations of adhesion and chemoattractant receptors) that target their migration to specific tissues and microenvironments. Cytokines contribute, but, for gut and skin, evolution has cleverly adapted external cues from food (vitamin A) and sunlight (ultraviolet-induced vitamin D3) to imprint lymphocyte homing to the small intestines and T cell migration into the epidermis. Dendritic cells are essential: they process the vitamins to their active metabolites (retinoic acid and 1,25(OH)
2
D3) for presentation with antigen to lymphocytes, and they help export environmental cues through lymphatics to draining lymph nodes, to program the trafficking and effector functions of naive T and B cells.</description><identifier>ISSN: 1529-2908</identifier><identifier>EISSN: 1529-2916</identifier><identifier>DOI: 10.1038/ni.f.208</identifier><identifier>PMID: 18711435</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Adhesion ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Cell Adhesion Molecules - physiology ; Cell Movement - physiology ; Dendritic cells ; Dendritic Cells - immunology ; Dendritic Cells - metabolism ; Epidermis ; Humans ; Immune response ; Immunologic Memory ; Immunology ; Infectious Diseases ; Lymph nodes ; Lymph Nodes - immunology ; Lymphocytes ; Metabolites ; Microenvironments ; Physiological aspects ; Properties ; Receptors, Lymphocyte Homing - physiology ; review-article ; Sunlight ; T-Lymphocyte Subsets - physiology ; Trafficking ; Vitamins</subject><ispartof>Nature immunology, 2008-09, Vol.9 (9), p.981-987</ispartof><rights>Springer Nature America, Inc. 2008</rights><rights>COPYRIGHT 2008 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Sep 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c618t-fb26bc8bc14f3e30e08959d2a906c12f249592b5ecc50722433b051a51bd6f2a3</citedby><cites>FETCH-LOGICAL-c618t-fb26bc8bc14f3e30e08959d2a906c12f249592b5ecc50722433b051a51bd6f2a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,2727,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18711435$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Butcher, Eugene C</creatorcontrib><creatorcontrib>Sigmundsdottir, Hekla</creatorcontrib><title>Environmental cues, dendritic cells and the programming of tissue-selective lymphocyte trafficking</title><title>Nature immunology</title><addtitle>Nat Immunol</addtitle><addtitle>Nat Immunol</addtitle><description>Lymphocytes are imprinted during activation with trafficking programs (combinations of adhesion and chemoattractant receptors) that target their migration to specific tissues and microenvironments. Cytokines contribute, but, for gut and skin, evolution has cleverly adapted external cues from food (vitamin A) and sunlight (ultraviolet-induced vitamin D3) to imprint lymphocyte homing to the small intestines and T cell migration into the epidermis. Dendritic cells are essential: they process the vitamins to their active metabolites (retinoic acid and 1,25(OH)
2
D3) for presentation with antigen to lymphocytes, and they help export environmental cues through lymphatics to draining lymph nodes, to program the trafficking and effector functions of naive T and B cells.</description><subject>Adhesion</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Adhesion Molecules - physiology</subject><subject>Cell Movement - physiology</subject><subject>Dendritic cells</subject><subject>Dendritic Cells - immunology</subject><subject>Dendritic Cells - metabolism</subject><subject>Epidermis</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immunologic Memory</subject><subject>Immunology</subject><subject>Infectious Diseases</subject><subject>Lymph nodes</subject><subject>Lymph Nodes - immunology</subject><subject>Lymphocytes</subject><subject>Metabolites</subject><subject>Microenvironments</subject><subject>Physiological aspects</subject><subject>Properties</subject><subject>Receptors, Lymphocyte Homing - physiology</subject><subject>review-article</subject><subject>Sunlight</subject><subject>T-Lymphocyte Subsets - physiology</subject><subject>Trafficking</subject><subject>Vitamins</subject><issn>1529-2908</issn><issn>1529-2916</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkmuLEzEUhgdR3LUK_gIZFLyArTlJ5vZFWJZVFxYEL59DJnMyzTqT1CRT7L83paW14oV8yOU85w3nPSfLHgNZAGH1G2sWekFJfSc7h4I2c9pAefdwJvVZ9iCEW0KAVyW_n51BXQFwVpxn7ZVdG-_siDbKIVcThtd5h7bzJhqVKxyGkEvb5XGJ-cq73stxNLbPnc6jCWHCecABVTRrzIfNuFo6tYmYRy-1NupbQh9m97QcAj7a77Ps67urL5cf5jcf319fXtzMVQl1nOuWlq2qWwVcM2QESd0UTUdlQ0oFVFOerrQtUKmCVJRyxlpSgCyg7UpNJZtlb3e6q6kdsVOpIi8HsfJmlH4jnDTiNGLNUvRuLRhUQCueBF7sBbz7noyIYjRh64C06KYg6gJ4CQy25PN_kmXDOWnI_0FKmopWqYez7Olv4K2bvE1-CUppxSpSQYKe7aBeDiiM1S7VobaK4gIawlgypUnU4g9UWh2ORjmL2qT3k4RXJwmJifgj9nIKQVx__nTKvtyxyrsQPOqDv0DEdhaTq0KnuuqEPvm1H0dwP3zHf0MK2R79sea_i1kZJ48HsQPwEz3y8ZE</recordid><startdate>20080901</startdate><enddate>20080901</enddate><creator>Butcher, Eugene C</creator><creator>Sigmundsdottir, Hekla</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20080901</creationdate><title>Environmental cues, dendritic cells and the programming of tissue-selective lymphocyte trafficking</title><author>Butcher, Eugene C ; Sigmundsdottir, Hekla</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c618t-fb26bc8bc14f3e30e08959d2a906c12f249592b5ecc50722433b051a51bd6f2a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adhesion</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell Adhesion Molecules - physiology</topic><topic>Cell Movement - physiology</topic><topic>Dendritic cells</topic><topic>Dendritic Cells - immunology</topic><topic>Dendritic Cells - metabolism</topic><topic>Epidermis</topic><topic>Humans</topic><topic>Immune response</topic><topic>Immunologic Memory</topic><topic>Immunology</topic><topic>Infectious Diseases</topic><topic>Lymph nodes</topic><topic>Lymph Nodes - immunology</topic><topic>Lymphocytes</topic><topic>Metabolites</topic><topic>Microenvironments</topic><topic>Physiological aspects</topic><topic>Properties</topic><topic>Receptors, Lymphocyte Homing - physiology</topic><topic>review-article</topic><topic>Sunlight</topic><topic>T-Lymphocyte Subsets - physiology</topic><topic>Trafficking</topic><topic>Vitamins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Butcher, Eugene C</creatorcontrib><creatorcontrib>Sigmundsdottir, Hekla</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nature immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Butcher, Eugene C</au><au>Sigmundsdottir, Hekla</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Environmental cues, dendritic cells and the programming of tissue-selective lymphocyte trafficking</atitle><jtitle>Nature immunology</jtitle><stitle>Nat Immunol</stitle><addtitle>Nat Immunol</addtitle><date>2008-09-01</date><risdate>2008</risdate><volume>9</volume><issue>9</issue><spage>981</spage><epage>987</epage><pages>981-987</pages><issn>1529-2908</issn><eissn>1529-2916</eissn><abstract>Lymphocytes are imprinted during activation with trafficking programs (combinations of adhesion and chemoattractant receptors) that target their migration to specific tissues and microenvironments. Cytokines contribute, but, for gut and skin, evolution has cleverly adapted external cues from food (vitamin A) and sunlight (ultraviolet-induced vitamin D3) to imprint lymphocyte homing to the small intestines and T cell migration into the epidermis. Dendritic cells are essential: they process the vitamins to their active metabolites (retinoic acid and 1,25(OH)
2
D3) for presentation with antigen to lymphocytes, and they help export environmental cues through lymphatics to draining lymph nodes, to program the trafficking and effector functions of naive T and B cells.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>18711435</pmid><doi>10.1038/ni.f.208</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1529-2908 |
| ispartof | Nature immunology, 2008-09, Vol.9 (9), p.981-987 |
| issn | 1529-2908 1529-2916 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3171274 |
| source | MEDLINE; Nature Journals Online; Alma/SFX Local Collection |
| subjects | Adhesion Animals Biomedical and Life Sciences Biomedicine Cell Adhesion Molecules - physiology Cell Movement - physiology Dendritic cells Dendritic Cells - immunology Dendritic Cells - metabolism Epidermis Humans Immune response Immunologic Memory Immunology Infectious Diseases Lymph nodes Lymph Nodes - immunology Lymphocytes Metabolites Microenvironments Physiological aspects Properties Receptors, Lymphocyte Homing - physiology review-article Sunlight T-Lymphocyte Subsets - physiology Trafficking Vitamins |
| title | Environmental cues, dendritic cells and the programming of tissue-selective lymphocyte trafficking |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T15%3A55%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Environmental%20cues,%20dendritic%20cells%20and%20the%20programming%20of%20tissue-selective%20lymphocyte%20trafficking&rft.jtitle=Nature%20immunology&rft.au=Butcher,%20Eugene%20C&rft.date=2008-09-01&rft.volume=9&rft.issue=9&rft.spage=981&rft.epage=987&rft.pages=981-987&rft.issn=1529-2908&rft.eissn=1529-2916&rft_id=info:doi/10.1038/ni.f.208&rft_dat=%3Cgale_pubme%3EA190332439%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=222737071&rft_id=info:pmid/18711435&rft_galeid=A190332439&rfr_iscdi=true |