Mitochondrial recoupling: a novel therapeutic strategy for cancer?
Recent findings link metabolic transformation of cancer cells to aberrant functions of mitochondrial uncoupling proteins (UCPs). By inducing proton leak, UCPs interfere with mitochondrial synthesis of adenosine 5′-triphosphate, which is also a key determinant of glycolytic pathways. In addition, UCP...
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| Veröffentlicht in: | British journal of cancer 2011-08, Vol.105 (4), p.469-474 |
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| creator | Baffy, G Derdak, Z Robson, S C |
| description | Recent findings link metabolic transformation of cancer cells to aberrant functions of mitochondrial uncoupling proteins (UCPs). By inducing proton leak, UCPs interfere with mitochondrial synthesis of adenosine 5′-triphosphate, which is also a key determinant of glycolytic pathways. In addition, UCP suppress the generation of superoxide, a byproduct of mitochondrial electron transport and a major source of oxidative stress. The near ubiquitous UCP2 becomes highly abundant in some cancers and may advance metabolic reprogramming, further disrupt tumour suppression, and promote chemoresistance. Here we review current evidence to suggest that inhibition of mitochondrial uncoupling may eliminate these responses and reveal novel anti-cancer strategies. |
| doi_str_mv | 10.1038/bjc.2011.245 |
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By inducing proton leak, UCPs interfere with mitochondrial synthesis of adenosine 5′-triphosphate, which is also a key determinant of glycolytic pathways. In addition, UCP suppress the generation of superoxide, a byproduct of mitochondrial electron transport and a major source of oxidative stress. The near ubiquitous UCP2 becomes highly abundant in some cancers and may advance metabolic reprogramming, further disrupt tumour suppression, and promote chemoresistance. 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| subjects | 631/443/319/333 631/92/555 692/699/67 Adenosine Adenosine Triphosphate - metabolism Animals Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Drug Resistance Drug Resistance, Neoplasm - drug effects Epidemiology Glycolysis Humans Ion Channels - antagonists & inhibitors Ion Channels - metabolism Medical research Medical sciences Medicine Membrane Transport Proteins - metabolism Metabolism mini-review Minireview Mitochondria Mitochondrial Proteins - antagonists & inhibitors Mitochondrial Proteins - metabolism Molecular Medicine Neoplasms - drug therapy Neoplasms - metabolism Oncology Oxidation-Reduction Oxidative Phosphorylation Oxidative stress Oxidative Stress - drug effects Phosphorylation Proteins Protons Superoxides - metabolism Thermogenesis Tumor Suppressor Protein p53 - metabolism Tumors Uncoupling Agents - metabolism Uncoupling Agents - pharmacology Uncoupling Protein 1 Uncoupling Protein 2 |
| title | Mitochondrial recoupling: a novel therapeutic strategy for cancer? |
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