AKAP-Lbc Mobilizes a Cardiac Hypertrophy Signaling Pathway

Elevated catecholamines in the heart evoke transcriptional activation of the Myocyte Enhancer Factor (MEF) pathway to induce a cellular response known as pathological myocardial hypertrophy. We have discovered that the A-Kinase Anchoring Protein (AKAP)-Lbc is upregulated in hypertrophic cardiomyocyt...

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Veröffentlicht in:	Molecular cell 2008-10, Vol.32 (2), p.169-179
Hauptverfasser:	Carnegie, Graeme K., Soughayer, Joseph, Smith, F. Donelson, Pedroja, Benjamin S., Zhang, Fang, Diviani, Dario, Bristow, Michael R., Kunkel, Maya T., Newton, Alexandra C., Langeberg, Lorene K., Scott, John D.
Format:	Artikel
Sprache:	eng
Schlagworte:	14-3-3 Proteins - metabolism A Kinase Anchor Proteins - genetics A Kinase Anchor Proteins - metabolism A Kinase Anchor Proteins - physiology Active Transport, Cell Nucleus Animals Cardiomegaly - metabolism Cell Line Cercopithecus aethiops COS Cells Cyclic AMP-Dependent Protein Kinases - metabolism Gene Expression Regulation Guanine Nucleotide Exchange Factors - genetics Guanine Nucleotide Exchange Factors - metabolism Guanine Nucleotide Exchange Factors - physiology Heart Ventricles - drug effects Histone Deacetylases - metabolism Humans HUMDISEASE MEF2 Transcription Factors Minor Histocompatibility Antigens Models, Biological Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Myogenic Regulatory Factors - metabolism Phenylephrine - pharmacology Phosphorylation Protein Kinase C - metabolism Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins - physiology Rats RNA Interference Signal Transduction SIGNALING
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