Probing conformational states of glutaryl-CoA dehydrogenase by fragment screening

Glutaric acidemia type 1 is an inherited metabolic disorder which can cause macrocephaly, muscular rigidity, spastic paralysis and other progressive movement disorders in humans. The defects in glutaryl‐CoA dehydrogenase (GCDH) associated with this disease are thought to increase holoenzyme instabil...

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Veröffentlicht in:	Acta crystallographica. Section F, Structural biology and crystallization communications Structural biology and crystallization communications, 2011-09, Vol.67 (9), p.1060-1069
Hauptverfasser:	Begley, Darren W., Davies, Douglas R., Hartley, Robert C., Hewitt, Stephen N., Rychel, Amanda L., Myler, Peter J., Van Voorhis, Wesley C., Staker, Bart L., Stewart, Lance J.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES ADENINES Apoenzymes - chemistry Backbone BASIC BIOLOGICAL SCIENCES Binding Burkholderia pseudomallei Burkholderia pseudomallei - enzymology Catalytic Domain crotonyl-CoA Crystallography, X-Ray DEFECTS DISEASES Disorders ENZYMES flavin adenine dinucleotide flavoproteins fragment screening Fragmentation glutaric acidemia glutaryl-CoA glutaryl-CoA dehydrogenase Glutaryl-CoA Dehydrogenase - chemistry Human Humans INSTABILITY ISOALLOXAZINES Models, Molecular OXIDOREDUCTASES pantothenate Phylogeny PROBES Protein Structure, Quaternary PROTEINS RESIDUES SSGCID Structural Communications Structural Homology, Protein
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