Neurovascular Injury in Acute Hyperglycemia and Diabetes: a Comparative Analysis in Experimental Stroke
Admission hyperglycemia impacts ischemic stroke deleteriously, but the relative role of acute hyperglycemia (HG) vs diabetes in the pathogenesis of this poor outcome is not clear. The study aims to determine the effect of acute HG on neurovascular outcomes of stroke under control and diabetic condit...
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| Veröffentlicht in: | Translational stroke research 2011-09, Vol.2 (3), p.391-398 |
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| creator | Elgebaly, Mostafa M. Ogbi, Safia Li, Weiguo Mezzetti, Erin M. Prakash, Roshini Johnson, Maribeth H. Bruno, Askiel Fagan, Susan C. Ergul, Adviye |
| description | Admission hyperglycemia impacts ischemic stroke deleteriously, but the relative role of acute hyperglycemia (HG) vs diabetes in the pathogenesis of this poor outcome is not clear. The study aims to determine the effect of acute HG on neurovascular outcomes of stroke under control and diabetic conditions. Moderate acute HG (140–200 mg/dl) was achieved by glucose injection before middle cerebral artery occlusion (MCAO) in control Wistar and diabetic Goto-Kakizaki rats. Following 3 h MCAO/21 h reperfusion, we measured infarct size, hemorrhagic transformation (HT) frequency, excess hemoglobin, neurobehavioral outcome, and MCA matrix metalloprotease activity. Infarct size was significantly smaller in diabetic rats. Moderate acute HG increased neuronal damage in diabetic but not in control rats. HT frequency and hemoglobin were significantly higher in diabetic rats. HG augmented vascular damage in control rats and had no additional effect on bleeding in diabetic rats. Neurological deficit was greater in diabetic rats and was worsened by HG. The finding that functional outcome is poorer in both acute HG and diabetes without a significant increase in infarct size suggests that amplified vascular damage contributes to neurological deficit in hyperglycemia. These results highlight the importance of vascular protection to improve neurological outcome in acute ischemic stroke. |
| doi_str_mv | 10.1007/s12975-011-0083-3 |
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The study aims to determine the effect of acute HG on neurovascular outcomes of stroke under control and diabetic conditions. Moderate acute HG (140–200 mg/dl) was achieved by glucose injection before middle cerebral artery occlusion (MCAO) in control Wistar and diabetic Goto-Kakizaki rats. Following 3 h MCAO/21 h reperfusion, we measured infarct size, hemorrhagic transformation (HT) frequency, excess hemoglobin, neurobehavioral outcome, and MCA matrix metalloprotease activity. Infarct size was significantly smaller in diabetic rats. Moderate acute HG increased neuronal damage in diabetic but not in control rats. HT frequency and hemoglobin were significantly higher in diabetic rats. HG augmented vascular damage in control rats and had no additional effect on bleeding in diabetic rats. Neurological deficit was greater in diabetic rats and was worsened by HG. The finding that functional outcome is poorer in both acute HG and diabetes without a significant increase in infarct size suggests that amplified vascular damage contributes to neurological deficit in hyperglycemia. These results highlight the importance of vascular protection to improve neurological outcome in acute ischemic stroke.</description><identifier>ISSN: 1868-4483</identifier><identifier>EISSN: 1868-601X</identifier><identifier>DOI: 10.1007/s12975-011-0083-3</identifier><identifier>PMID: 21909340</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Animals ; Biomedical and Life Sciences ; Biomedicine ; Cardiology ; Carotid arteries ; Diabetes ; Edema ; Glucose ; Hyperglycemia ; Insulin resistance ; Ischemia ; Neurology ; Neurosciences ; Neurosurgery ; Original Article ; Stroke ; Vascular Surgery ; Veins & arteries</subject><ispartof>Translational stroke research, 2011-09, Vol.2 (3), p.391-398</ispartof><rights>Springer Science+Business Media, LLC 2011</rights><rights>Springer Science+Business Media, LLC 2011.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-15e4d2c2ccc79bba69312bf9ba6d2ab55429057351ca1433fe01178a2f5df6143</citedby><cites>FETCH-LOGICAL-c470t-15e4d2c2ccc79bba69312bf9ba6d2ab55429057351ca1433fe01178a2f5df6143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12975-011-0083-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2920256484?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,776,780,881,21368,21369,27903,27904,33509,33510,33723,33724,41467,42536,43638,43784,51297,64361,64363,64365,72215</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21909340$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Elgebaly, Mostafa M.</creatorcontrib><creatorcontrib>Ogbi, Safia</creatorcontrib><creatorcontrib>Li, Weiguo</creatorcontrib><creatorcontrib>Mezzetti, Erin M.</creatorcontrib><creatorcontrib>Prakash, Roshini</creatorcontrib><creatorcontrib>Johnson, Maribeth H.</creatorcontrib><creatorcontrib>Bruno, Askiel</creatorcontrib><creatorcontrib>Fagan, Susan C.</creatorcontrib><creatorcontrib>Ergul, Adviye</creatorcontrib><title>Neurovascular Injury in Acute Hyperglycemia and Diabetes: a Comparative Analysis in Experimental Stroke</title><title>Translational stroke research</title><addtitle>Transl. Stroke Res</addtitle><addtitle>Transl Stroke Res</addtitle><description>Admission hyperglycemia impacts ischemic stroke deleteriously, but the relative role of acute hyperglycemia (HG) vs diabetes in the pathogenesis of this poor outcome is not clear. The study aims to determine the effect of acute HG on neurovascular outcomes of stroke under control and diabetic conditions. Moderate acute HG (140–200 mg/dl) was achieved by glucose injection before middle cerebral artery occlusion (MCAO) in control Wistar and diabetic Goto-Kakizaki rats. Following 3 h MCAO/21 h reperfusion, we measured infarct size, hemorrhagic transformation (HT) frequency, excess hemoglobin, neurobehavioral outcome, and MCA matrix metalloprotease activity. Infarct size was significantly smaller in diabetic rats. Moderate acute HG increased neuronal damage in diabetic but not in control rats. HT frequency and hemoglobin were significantly higher in diabetic rats. HG augmented vascular damage in control rats and had no additional effect on bleeding in diabetic rats. Neurological deficit was greater in diabetic rats and was worsened by HG. The finding that functional outcome is poorer in both acute HG and diabetes without a significant increase in infarct size suggests that amplified vascular damage contributes to neurological deficit in hyperglycemia. These results highlight the importance of vascular protection to improve neurological outcome in acute ischemic stroke.</description><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cardiology</subject><subject>Carotid arteries</subject><subject>Diabetes</subject><subject>Edema</subject><subject>Glucose</subject><subject>Hyperglycemia</subject><subject>Insulin resistance</subject><subject>Ischemia</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Neurosurgery</subject><subject>Original Article</subject><subject>Stroke</subject><subject>Vascular Surgery</subject><subject>Veins & arteries</subject><issn>1868-4483</issn><issn>1868-601X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1UU1v1DAQtRCIVqU_gAuyxIVLwJ9JzAFptS20UgUHQOJmTZzJ4iWJFztZkX-PV7uUDwlfPPK89_xmHiFPOXvJGateJS5MpQvGecFYLQv5gJzzuqyLkvEvD0-1UrU8I5cpbVk-kqtSycfkTHDDjFTsnGze4xzDHpKbe4j0dtzOcaF-pCs3T0hvlh3GTb84HDxQGFt65aHBCdNrCnQdhh1EmPwe6WqEfkk-HbjXPzLLDzhO0NOPUwzf8Al51EGf8PJ0X5DPb68_rW-Kuw_vbteru8Kpik0F16ha4YRzrjJNA6WRXDSdyVUroNFaCcN0JTV3wJWUHeb5qxpEp9uuzC8X5M1Rdzc3A7Yue4jQ2122A3GxAbz9uzP6r3YT9lby0mSlLPDiJBDD9xnTZAefHPY9jBjmZPMKK1bmHesMff4PdBvmmPeQrDCCCV2q-uCIH1EuhpQidvdmOLOHJO0xSZsnsYckrcycZ39Occ_4lVsGiCMg5da4wfj76_-r_gSBuaoE</recordid><startdate>20110901</startdate><enddate>20110901</enddate><creator>Elgebaly, Mostafa M.</creator><creator>Ogbi, Safia</creator><creator>Li, Weiguo</creator><creator>Mezzetti, Erin M.</creator><creator>Prakash, Roshini</creator><creator>Johnson, Maribeth H.</creator><creator>Bruno, Askiel</creator><creator>Fagan, Susan C.</creator><creator>Ergul, Adviye</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110901</creationdate><title>Neurovascular Injury in Acute Hyperglycemia and Diabetes: a Comparative Analysis in Experimental Stroke</title><author>Elgebaly, Mostafa M. ; 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| subjects | Animals Biomedical and Life Sciences Biomedicine Cardiology Carotid arteries Diabetes Edema Glucose Hyperglycemia Insulin resistance Ischemia Neurology Neurosciences Neurosurgery Original Article Stroke Vascular Surgery Veins & arteries |
| title | Neurovascular Injury in Acute Hyperglycemia and Diabetes: a Comparative Analysis in Experimental Stroke |
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