AKAPs: The architectural underpinnings of local cAMP signaling

Abstract The cAMP-dependent protein kinase A (PKA) is targeted to specific compartments in the cardiac myocyte by A-kinase anchoring proteins (AKAPs), a diverse set of scaffold proteins that have been implicated in the regulation of excitation–contraction coupling and cardiac remodeling. AKAPs bind...

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Veröffentlicht in:	Journal of molecular and cellular cardiology 2012-02, Vol.52 (2), p.351-358
Hauptverfasser:	Kritzer, Michael D, Li, Jinliang, Dodge-Kafka, Kimberly, Kapiloff, Michael S
Format:	Artikel
Sprache:	eng
Schlagworte:	A Kinase Anchor Proteins - metabolism AKAP Animals cAMP Cardiovascular Compartmentation Cyclic AMP - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism Humans Myocytes, Cardiac - metabolism PKA Protein Binding Sarcomeres - metabolism Scaffold Second Messenger Systems - physiology Signal Transduction Signaling
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