The Dlk1 and Gtl2 genes are linked and reciprocally imprinted
Genes subject to genomic imprinting exist in large chromosomal domains, probably reflecting coordinate regulation of the genes within a cluster. Such regulation has been demonstrated for the H19, Igf2, and Ins2 genes that share a bifunctional imprinting control region. We have identified the Dlk1 ge...
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| Veröffentlicht in: | Genes & development 2000-08, Vol.14 (16), p.1997-2002 |
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| container_end_page | 2002 |
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| container_issue | 16 |
| container_start_page | 1997 |
| container_title | Genes & development |
| container_volume | 14 |
| creator | Schmidt, J V Matteson, P G Jones, B K Guan, X J Tilghman, S M |
| description | Genes subject to genomic imprinting exist in large chromosomal domains, probably reflecting coordinate regulation of the genes within a cluster. Such regulation has been demonstrated for the H19, Igf2, and Ins2 genes that share a bifunctional imprinting control region. We have identified the Dlk1 gene as a new imprinted gene that is paternally expressed. Furthermore, we show that Dlk1 is tightly linked to the maternally expressed Gtl2 gene. Dlk1 and Gtl2 are coexpressed and respond in a reciprocal manner to loss of DNA methylation. These genes are likely to represent a new example of coordinated imprinting of linked genes. |
| doi_str_mv | 10.1101/gad.14.16.1997 |
| format | Article |
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These genes are likely to represent a new example of coordinated imprinting of linked genes.</description><subject>Animals</subject><subject>Base Sequence</subject><subject>Chromosome Mapping</subject><subject>Dlk1 gene</subject><subject>DNA Methylation</subject><subject>DNA Primers</subject><subject>Female</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Genetic Linkage</subject><subject>Genomic Imprinting</subject><subject>Gt12 gene</subject><subject>Muridae - genetics</subject><subject>Peromyscus - genetics</subject><subject>Research Communication</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><issn>0890-9369</issn><issn>1549-5477</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkb1P5DAQxa0Tp2PZu_ZKlIouYSZ2_FFQIL4lJJq92nKcyZLDmyx2Fmn_e7IsQlBRTfHeG72nH2N_EQpEwNOlawoUBcoCjVE_2AwrYfJKKHXAZqAN5IZLc8iOUvoPABKk_MUOEUwFWooZO1s8UnYZnjBzfZPdjKHMltRTylykLHT9EzVvSiTfrePgXQjbrFutY9eP1PxmP1sXEv15v3P27_pqcXGb3z_c3F2c3-de6HLMBec1tqX3IHhNnJSRRgNv2rqm2rSKS-2gnvbUJejSAzdSqMaTVCUK8hWfs7P93_WmXtGk9GN0wU4tVi5u7eA6-1Xpu0e7HF4sR6krNeVP3vNxeN5QGu2qS55CcD0Nm2QVKil0Bd8aJx_qSu4aFXujj0NKkdqPMgh2R8ZOZCwKi9LuyEyB488TPtn3KPgrRzeJZw</recordid><startdate>20000815</startdate><enddate>20000815</enddate><creator>Schmidt, J V</creator><creator>Matteson, P G</creator><creator>Jones, B K</creator><creator>Guan, X J</creator><creator>Tilghman, S M</creator><general>Cold Spring Harbor Laboratory Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20000815</creationdate><title>The Dlk1 and Gtl2 genes are linked and reciprocally imprinted</title><author>Schmidt, J V ; Matteson, P G ; Jones, B K ; Guan, X J ; Tilghman, S M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c482t-433b1f2cc043be3e7969803dfbbeb9f7368a0b110b2082c039647dce67214ec53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Base Sequence</topic><topic>Chromosome Mapping</topic><topic>Dlk1 gene</topic><topic>DNA Methylation</topic><topic>DNA Primers</topic><topic>Female</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Genetic Linkage</topic><topic>Genomic Imprinting</topic><topic>Gt12 gene</topic><topic>Muridae - genetics</topic><topic>Peromyscus - genetics</topic><topic>Research Communication</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schmidt, J V</creatorcontrib><creatorcontrib>Matteson, P G</creatorcontrib><creatorcontrib>Jones, B K</creatorcontrib><creatorcontrib>Guan, X J</creatorcontrib><creatorcontrib>Tilghman, S M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Genes & development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schmidt, J V</au><au>Matteson, P G</au><au>Jones, B K</au><au>Guan, X J</au><au>Tilghman, S M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Dlk1 and Gtl2 genes are linked and reciprocally imprinted</atitle><jtitle>Genes & development</jtitle><addtitle>Genes Dev</addtitle><date>2000-08-15</date><risdate>2000</risdate><volume>14</volume><issue>16</issue><spage>1997</spage><epage>2002</epage><pages>1997-2002</pages><issn>0890-9369</issn><eissn>1549-5477</eissn><abstract>Genes subject to genomic imprinting exist in large chromosomal domains, probably reflecting coordinate regulation of the genes within a cluster. Such regulation has been demonstrated for the H19, Igf2, and Ins2 genes that share a bifunctional imprinting control region. We have identified the Dlk1 gene as a new imprinted gene that is paternally expressed. Furthermore, we show that Dlk1 is tightly linked to the maternally expressed Gtl2 gene. Dlk1 and Gtl2 are coexpressed and respond in a reciprocal manner to loss of DNA methylation. These genes are likely to represent a new example of coordinated imprinting of linked genes.</abstract><cop>United States</cop><pub>Cold Spring Harbor Laboratory Press</pub><pmid>10950864</pmid><doi>10.1101/gad.14.16.1997</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Genes & development, 2000-08, Vol.14 (16), p.1997-2002 |
| issn | 0890-9369 1549-5477 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals Base Sequence Chromosome Mapping Dlk1 gene DNA Methylation DNA Primers Female Gene Expression Regulation, Developmental Genetic Linkage Genomic Imprinting Gt12 gene Muridae - genetics Peromyscus - genetics Research Communication Reverse Transcriptase Polymerase Chain Reaction |
| title | The Dlk1 and Gtl2 genes are linked and reciprocally imprinted |
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