Role of SHV β-lactamase variants in resistance of clinical Klebsiella pneumoniae strains to β-lactams in an Algerian hospital

Three clinical Klebsiella pneumoniae strains, KpARG74, KpARG220 and KpARG185, isolated from a hospital in Algeria, carried the novel β-lactamases SHV-98, SHV-99 and SHV-100, respectively, and co-expressed TEM-1 and either CTX-M-3 or CTX-M-15. In contrast, transformed cells possessing the genes for t...

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Veröffentlicht in:	Journal of medical microbiology 2011-07, Vol.60 (7), p.983-987
Hauptverfasser:	RAMDANI-BOUGUESSA, Nadjia, MANAGEIRO, Vera, JONES-DIAS, Daniela, FERREIRA, Eugénia, TAZIR, Mohamed, CANICA, Manuela
Format:	Artikel
Sprache:	eng
Schlagworte:	Algeria - epidemiology Amino acid sequence Amino acid substitution Anti-Bacterial Agents - pharmacology Antimicrobial Agents and Chemotherapy Aztreonam Bacteriology beta -Lactam antibiotics beta -Lactamase beta-Lactam Resistance beta-Lactamases - genetics beta-Lactamases - metabolism Biological and medical sciences Enzymes Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Bacterial - physiology Gene Expression Regulation, Enzymologic Glycine Hospitals Humans Infectious diseases Kinetics Klebsiella Infections - epidemiology Klebsiella Infections - microbiology Klebsiella pneumoniae Klebsiella pneumoniae - drug effects Klebsiella pneumoniae - enzymology Klebsiella pneumoniae - genetics Medical sciences Microbial Sensitivity Tests Microbiology Miscellaneous Mutation Pathogens Transformed cells
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