Knockdown of the β1 integrin subunit reduces primary tumor growth and inhibits pancreatic cancer metastasis

To address the role of β1 integrins in pancreatic cancer progression, we stably knocked down β1 integrin subunit expression in human FG‐RFP pancreatic cancer cells using lentiviral‐based RNA interference. We then examined the effects of β1 integrin subunit knockdown on pancreatic cancer cell adhesio...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	International journal of cancer 2011-12, Vol.129 (12), p.2905-2915
Hauptverfasser:	Grzesiak, John J., Cao, Hop S. Tran, Burton, Douglas W., Kaushal, Sharmeela, Vargas, Fabian, Clopton, Paul, Snyder, Cynthia S., Deftos, Leonard J., Hoffman, Robert M., Bouvet, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences extracellular matrix Gastroenterology. Liver. Pancreas. Abdomen integrins Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences orthotopic mouse models pancreatic cancer RNA interference Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!