Killing kinetics of fidaxomicin and its major metabolite, OP-1118, against Clostridium difficile

The kinetics of bacterial killing for fidaxomicin and its major metabolite, OP-1118, were investigated against Clostridium difficile strains, including two clinical strains belonging to the restriction endonuclease analysis group BI (ORG 1687 and 1698), the ATCC 43255 strain and two laboratory-deriv...

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Veröffentlicht in:	Journal of medical microbiology 2011-08, Vol.60 (Pt 8), p.1213-1217
Hauptverfasser:	Babakhani, Farah, Gomez, Abraham, Robert, Nikki, Sears, Pamela
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoglycosides - metabolism Aminoglycosides - pharmacology Anti-Bacterial Agents - metabolism Anti-Bacterial Agents - pharmacology Clostridioides difficile - drug effects Clostridioides difficile - genetics Clostridium Difficile Drug Resistance, Bacterial Endonuclease Fidaxomicin Kinetics Metabolites Microbial Sensitivity Tests Minimum inhibitory concentration Oral administration Time Factors Vancomycin - pharmacology
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