OCT4 establishes and maintains nucleosome-depleted regions that provide additional layers of epigenetic regulation of its target genes

Recent epigenome-wide mapping studies describe nucleosome-depleted regions (NDRs) at transcription start sites and enhancers. However, these static maps do not address causality or the roles of NDRs in gene control, and their relationship to transcription factors and DNA methylation is not well unde...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-08, Vol.108 (35), p.14497-14502
Hauptverfasser:	You, Jueng Soo, Kelly, Theresa K, De Carvalho, Daniel D, Taberlay, Phillippa C, Liang, Gangning, Jones, Peter A
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences Cell Differentiation Cell lines Cells Cells, Cultured CpG Islands Cytosine Data processing Differentiation DNA DNA Methylation Embryonic stem cells Enhancers Epigenesis, Genetic Epigenetics Gene Expression Regulation Gene mapping Genes Genomics HCT116 cells Homeodomain Proteins - physiology Humans Methylation Nanog Homeobox Protein Nucleosomes Nucleosomes - physiology Oct-4 protein Octamer Transcription Factor-3 - physiology Pluripotent stem cells Promoters Somatic cells Stem cells Transcription factors
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