Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice

The recent discovery of checkpoint kinases has suggested the conservation of checkpoint mechanisms between yeast and mammals. In yeast, the protein kinase Chk1 is thought to mediate signaling associated with the DNA damage checkpoint of the cell cycle. However, the function of Chk1 in mammals has re...

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Veröffentlicht in:	Genes & development 2000-06, Vol.14 (12), p.1439-1447
Hauptverfasser:	Takai, H, Tominaga, K, Motoyama, N, Minamishima, Y A, Nagahama, H, Tsukiyama, T, Ikeda, K, Nakayama, K, Nakanishi, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Animals, Newborn Apoptosis Blastocyst Cell Division - genetics Cell Nucleus - physiology Cells, Cultured Checkpoint Kinase 1 Crosses, Genetic DNA - biosynthesis DNA Damage Embryo, Mammalian - metabolism Fibroblasts - metabolism G2 Phase Genotype Humans Immunoblotting Immunohistochemistry In Situ Nick-End Labeling Mice Mice, Inbred C57BL Mice, Inbred ICR Mice, Transgenic Models, Genetic Mutagenesis Protein Kinases - genetics Protein Kinases - physiology Research Paper Stem Cells
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