CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

Cellular stress, particularly in response to toxic and metabolic insults that perturb function of the endoplasmic reticulum (ER stress), is a powerful inducer of the transcription factor CHOP. The role of CHOP in the response of cells to injury associated with ER stress was examined in a murine defi...

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Veröffentlicht in:	Genes & development 1998-04, Vol.12 (7), p.982-995
Hauptverfasser:	Zinszner, H, Kuroda, M, Wang, X, Batchvarova, N, Lightfoot, R T, Remotti, H, Stevens, J L, Ron, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - pharmacology Apoptosis - drug effects Apoptosis - genetics CCAAT-Enhancer-Binding Proteins Cells, Cultured - drug effects DNA-Binding Proteins - drug effects DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism DNA-Binding Proteins - physiology Endoplasmic Reticulum - drug effects Endoplasmic Reticulum - physiology Epithelium - drug effects Fibroblasts - drug effects Fibroblasts - physiology Kidney Tubules, Proximal - cytology Kidney Tubules, Proximal - drug effects Mice Nuclear Proteins - metabolism Research Paper Transcription Factor CHOP Transcription Factors - drug effects Transcription Factors - genetics Transcription Factors - metabolism Transcription Factors - physiology Tunicamycin - pharmacology
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