EGF domain swap converts a drosophila EGF receptor activator into an inhibitor

In Drosophila the function of the epidermal growth factor (EGF) receptor is modulated zygotically by three EGF-like proteins: Spitz (Spi), which is a potent activator; Vein (Vn), which is a moderate activator; and Argos (Aos), which is an inhibitor. Chimeric molecules were constructed in which the E...

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Veröffentlicht in:	Genes & development 1998-04, Vol.12 (7), p.908-913
Hauptverfasser:	Schnepp, B, Donaldson, T, Grumbling, G, Ostrowski, S, Schweitzer, R, Shilo, B Z, Simcox, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Drosophila - genetics Drosophila Proteins Epidermal Growth Factor - chemistry Epidermal Growth Factor - genetics Epidermal Growth Factor - physiology ErbB Receptors - agonists ErbB Receptors - antagonists & inhibitors ErbB Receptors - drug effects Eye - anatomy & histology Eye - drug effects Eye Proteins - chemistry Eye Proteins - genetics Genetic Engineering Insect Proteins - chemistry Insect Proteins - genetics Insect Proteins - pharmacology Insect Proteins - physiology Membrane Proteins - chemistry Membrane Proteins - genetics Molecular Sequence Data Nerve Tissue Proteins - chemistry Nerve Tissue Proteins - genetics Neuregulins Phenotype Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - pharmacology Research Communication Sequence Alignment Sequence Homology, Amino Acid Wings, Animal - anatomy & histology Wings, Animal - drug effects
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