Nrf2‐mediated liver protection by sauchinone, an antioxidant lignan, from acetaminophen toxicity through the PKCδ‐GSK3β pathway

BACKGROUND AND PURPOSE Sauchinone, an antioxidant lignan, protects hepatocytes from iron‐induced toxicity. This study investigated the protective effects of sauchinone against acetaminophen (APAP)‐induced toxicity in the liver and the role of nuclear factor erythroid‐2‐related factor‐2 (Nrf2) in thi...

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Veröffentlicht in:	British journal of pharmacology 2011-08, Vol.163 (8), p.1653-1665
Hauptverfasser:	Kay, Hee Yeon, Kim, Young Woo, Ryu, Da Hye, Sung, Sang Hyun, Hwang, Se Jin, Kim, Sang Geon
Format:	Artikel
Sprache:	eng
Schlagworte:	acetaminophen Acetaminophen - toxicity Analgesics, Non-Narcotic - toxicity Animals Antioxidants - chemistry Antioxidants - metabolism Antioxidants - pharmacology Benzopyrans - chemistry Benzopyrans - metabolism Benzopyrans - pharmacology Biological and medical sciences Dioxoles - chemistry Dioxoles - metabolism Dioxoles - pharmacology Glutathione - analysis Glycogen Synthase Kinase 3 - genetics Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta GSK3β Hep G2 Cells Humans Lignans - chemistry Lignans - metabolism Lignans - pharmacology Liver - drug effects Liver - injuries Liver - metabolism Liver - pathology Major Histocompatibility Complex - genetics Male Medical sciences Mice Mice, Inbred C57BL Mice, Knockout NF-E2-Related Factor 2 - physiology Nrf2 Pharmacology. Drug treatments Phytotherapy PKCδ Plant Preparations - chemistry Plant Preparations - metabolism Plant Preparations - pharmacology Protective Agents - chemistry Protective Agents - metabolism Protective Agents - pharmacology Protein Kinase C-delta - genetics Protein Kinase C-delta - metabolism Proteins - genetics Proteins - metabolism Research Papers sauchinone Saururaceae Signal Transduction - drug effects Signal Transduction - physiology
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