Cooperative effects of INK4a and ras in melanoma susceptibility in vivo

The familial melanoma gene (INK4a/MTS1/CDKN2) encodes potent tumor suppressor activity. Although mice null for the ink4a homolog develop a cancer-prone condition, a pathogenetic link to melanoma susceptibility has yet to be established. Here we report that mice with melanocyte-specific expression of...

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Veröffentlicht in:	Genes & development 1997-11, Vol.11 (21), p.2822-2834
Hauptverfasser:	Chin, L, Pomerantz, J, Polsky, D, Jacobson, M, Cohen, C, Cordon-Cardo, C, Horner, 2nd, J W, DePinho, R A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cyclin-Dependent Kinase Inhibitor p16 - biosynthesis Cyclin-Dependent Kinase Inhibitor p16 - deficiency Cyclin-Dependent Kinase Inhibitor p16 - genetics Disease Susceptibility DNA Primers Exons Eye Neoplasms - genetics Eye Neoplasms - pathology Genes, p16 Genes, ras Humans Melanoma - genetics Melanoma - pathology Melanoma - physiopathology Mice Mice, Knockout Mice, Transgenic Polymerase Chain Reaction Research Paper Skin Neoplasms - genetics Skin Neoplasms - pathology
Online-Zugang:	Volltext
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