Single Cell Responses to Spatially Controlled Photosensitized Production of Extracellular Singlet Oxygen

The response of individual HeLa cells to extracellularly produced singlet oxygen was examined. The spatial domain of singlet oxygen production was controlled using the combination of a membrane‐impermeable Pd porphyrin‐dendrimer, which served as a photosensitizer, and a focused laser, which served t...

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Veröffentlicht in:	Photochemistry and photobiology 2011-09, Vol.87 (5), p.1077-1091
Hauptverfasser:	Pedersen, Brian W., Sinks, Louise E., Breitenbach, Thomas, Schack, Nickolass B., Vinogradov, Sergei A., Ogilby, Peter R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Cell Death - drug effects Cell Death - radiation effects Cell Membrane - drug effects Cell Membrane - radiation effects Cells Extracellular Space Female HeLa Cells Humans Lasers Mesoporphyrins - pharmacology Metalloporphyrins - pharmacology Microscopy Morphology Mortality Oxygen Photobiology Photochemotherapy - methods Photosensitizing Agents - pharmacology Photosynthesis Single-Cell Analysis - instrumentation Single-Cell Analysis - methods Singlet Oxygen - adverse effects Singlet Oxygen - metabolism Ultraviolet Rays
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