SynGAP moves out of the core of the postsynaptic density upon depolarization

Abstract SynGAP is a Ras GTPase activating protein present at the postsynaptic density (PSD) in quantities matching those of the core scaffold protein PSD-95. SynGAP is reported to inhibit synaptic accumulation of AMPA receptors. Here, we characterize by immunogold electron microscopy the distributi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2011-09, Vol.192, p.132-139
Hauptverfasser:	Yang, Y, Tao-Cheng, J.-H, Reese, T.S, Dosemeci, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - physiology AMPA receptor Animals Biological and medical sciences Blotting, Western electron microscopy Fundamental and applied biological sciences. Psychology GTPase-Activating Proteins - metabolism Hippocampus - metabolism immunogold Immunohistochemistry Microscopy, Electron Neurology Neurons - metabolism Organ Culture Techniques Post-Synaptic Density - metabolism postsynaptic density Protein Transport - physiology PSD-95 Rats Rats, Sprague-Dawley SynGAP Vertebrates: nervous system and sense organs
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!