Histone deacetylase activity of Rpd3 is important for transcriptional repression in vivo

Eukaryotic organisms from yeast to human contain a multiprotein complex that includes Rpd3 histone deacetylase and Sin3 corepressor. The Sin3-Rpd3 complex, when recruited to promoters by specific DNA-binding proteins, can direct transcriptional repression of specific classes of target genes. It has...

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Veröffentlicht in:	Genes & development 1998-03, Vol.12 (6), p.797-805
Hauptverfasser:	Kadosh, D, Struhl, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Amino Acid Sequence Binding Sites - genetics Catalysis Fungal Proteins - metabolism Gene Expression Regulation, Fungal Histone Deacetylases - genetics Histone Deacetylases - metabolism Molecular Sequence Data Mutation - genetics Mutation - physiology Research Paper Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins Sequence Homology, Amino Acid Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic - genetics Transcription, Genetic - physiology
Online-Zugang:	Volltext
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