Inhibition of Human Melanoma Cell Growth by the Dietary Flavonoid Fisetin Is Associated with Disruption of Wnt/β-Catenin Signaling and Decreased Mitf Levels

The prognosis of advanced melanoma remains poor in spite of treatment advances, emphasizing the importance of additional preventive measures. Flavonoids, natural components of our diet, are being investigated for their chemopreventive/therapeutic properties. Microphthalmia-associated transcription f...

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Veröffentlicht in:	Journal of investigative dermatology 2011-06, Vol.131 (6), p.1291-1299
Hauptverfasser:	Syed, Deeba N., Afaq, Farrukh, Maddodi, Nityanand, Johnson, Jeremy J., Sarfaraz, Sami, Ahmad, Adeel, Setaluri, Vijayasaradhi, Mukhtar, Hasan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology beta Catenin - analysis beta Catenin - physiology beta-Transducin Repeat-Containing Proteins - physiology Biological and medical sciences Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Dermatology Diseases of the digestive system Female Flavonoids - pharmacology G1 Phase - drug effects Glycogen Synthase Kinase 3 - antagonists & inhibitors Glycogen Synthase Kinase 3 beta Hepatocyte Nuclear Factor 1-beta - physiology Humans Medical sciences Melanoma - drug therapy Melanoma - pathology Mice Microphthalmia-Associated Transcription Factor - antagonists & inhibitors Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Signal Transduction - drug effects Tumors of the skin and soft tissue. Premalignant lesions Wnt Proteins - physiology
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