Defective hematopoietic stem cell and lymphoid progenitor development in the Ts65Dn mouse model of Down syndrome: potential role of oxidative stress

Down Syndrome (DS), a genetic disease caused by a triplication of chromosome 21, is characterized by increased markers of oxidative stress. In addition to cognitive defects, patients with DS also display hematologic disorders and increased incidence of infections and leukemia. Using the Ts65Dn mouse...

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Veröffentlicht in:	Antioxidants & redox signaling 2011-10, Vol.15 (8), p.2083-2094
Hauptverfasser:	Lorenzo, Laureanne Pilar E, Chen, Haiyan, Shatynski, Kristen E, Clark, Sarah, Yuan, Rong, Harrison, David E, Yarowsky, Paul J, Williams, Mark S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Marrow Cells - cytology Development and progression Disease Models, Animal Down syndrome Down Syndrome - metabolism Down Syndrome - pathology Female Hematopoietic stem cells Hematopoietic Stem Cells - pathology Lymphoid Progenitor Cells - pathology Male Mice Mice, Mutant Strains Original Research Communications Oxidative Stress Physiological aspects Reactive Oxygen Species - metabolism Receptors, Interleukin-7 - metabolism
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