Effects of cannabinoids and cannabinoid‐enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes

BACKGROUND AND PURPOSE Cannabidiol (CBD) and Δ9‐tetrahydrocannabinol (THC) interact with transient receptor potential (TRP) channels and enzymes of the endocannabinoid system. EXPERIMENTAL APPROACH The effects of 11 pure cannabinoids and botanical extracts [botanical drug substance (BDS)] from Canna...

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Veröffentlicht in:	British journal of pharmacology 2011-08, Vol.163 (7), p.1479-1494
Hauptverfasser:	De Petrocellis, Luciano, Ligresti, Alessia, Moriello, Aniello Schiano, Allarà, Marco, Bisogno, Tiziana, Petrosino, Stefania, Stott, Colin G, Di Marzo, Vincenzo
Format:	Artikel
Sprache:	eng
Schlagworte:	Amidohydrolases - metabolism Animals Arachidonic Acids - metabolism botanical extract Cannabinoid Receptor Modulators - metabolism cannabinoids Cannabinoids - pharmacology cannabis Cannabis - chemistry Cercopithecus aethiops COS Cells diacylglycerol lipase endocannabinoid Endocannabinoids Enzymes Ethanolamines Glycerides - metabolism HEK293 Cells Humans Lipoprotein Lipase - metabolism monoacylglycerol lipase Monoacylglycerol Lipases - metabolism Palmitic Acids - metabolism Plant Extracts - pharmacology Polyunsaturated Alkamides - metabolism Rats Research Papers Rodents Transient Receptor Potential Channels - agonists Transient Receptor Potential Channels - antagonists & inhibitors Transient Receptor Potential Channels - metabolism TRP channel TRPA1 TRPM8 TRPV1
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