Enhanced Control of Pathogenic Simian Immunodeficiency Virus SIVmac239 Replication in Macaques Immunized with an Interleukin-12 Plasmid and a DNA Prime-Viral Vector Boost Vaccine Regimen

DNA priming has previously been shown to elicit augmented immune responses when administered by electroporation (EP) or codelivered with a plasmid encoding interleukin-12 (pIL-12). We hypothesized that the efficacy of a DNA prime and recombinant adenovirus 5 boost vaccination regimen (DNA/rAd5) woul...

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Veröffentlicht in:	Journal of Virology 2011-09, Vol.85 (18), p.9578-9587
Hauptverfasser:	Winstone, Nicola, Wilson, Aaron J, Morrow, Gavin, Boggiano, Cesar, Chiuchiolo, Maria J, Lopez, Mary, Kemelman, Marina, Ginsberg, Arielle A, Mullen, Karl, Coleman, John W, Wu, Chih-Da, Narpala, Sandeep, Ouellette, Ian, Dean, Hansi J, Lin, Feng, Sardesai, Niranjan Y, Cassamasa, Holly, McBride, Dawn, Felber, Barbara K, Pavlakis, George N, Schultz, Alan, Hudgens, Michael G, King, C. Richter, Zamb, Timothy J, Parks, Christopher L, McDermott, Adrian B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adjuvants, Immunologic - administration & dosage Adjuvants, Immunologic - genetics Animals antibodies Biological and medical sciences CD4-positive T-lymphocytes electroporation Fundamental and applied biological sciences. Psychology Genetic Vectors immune response Immunization, Secondary - methods interleukin-12 Interleukin-12 - administration & dosage Interleukin-12 - genetics lymph nodes Lymph Nodes - virology Macaca Macaca mulatta Microbiology Miscellaneous plasmids proteome RNA RNA, Viral - isolation & purification SAIDS Vaccines - administration & dosage SAIDS Vaccines - immunology Simian Acquired Immunodeficiency Syndrome - prevention & control Simian Acquired Immunodeficiency Syndrome - virology Simian immunodeficiency virus Simian Immunodeficiency Virus - genetics Simian Immunodeficiency Virus - immunology vaccination Vaccination - methods Vaccines and Antiviral Agents Vaccines, DNA - administration & dosage Vaccines, DNA - immunology Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - immunology Viral Load viremia Viremia - prevention & control Virology virus replication
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