The role of HLA–DR–DQ haplotypes in variable antibody responses to Anthrax Vaccine Adsorbed

Host genetic variation, particularly within the human leukocyte antigen (HLA) loci, reportedly mediates heterogeneity in immune response to certain vaccines; however, no large study of genetic determinants of anthrax vaccine response has been described. We searched for associations between the immun...

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Veröffentlicht in:	Genes and immunity 2011-09, Vol.12 (6), p.457-465
Hauptverfasser:	Pajewski, N M, Parker, S D, Poland, G A, Ovsyannikova, I G, Song, W, Zhang, K, McKinney, B A, Pankratz, V S, Edberg, J C, Kimberly, R P, Jacobson, R M, Tang, J, Kaslow, R A
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/457/649 631/250/590 692/699/255/1318 Adult African Americans Aged Alleles Anthrax Anthrax - immunology Anthrax Vaccines - immunology Antibodies Antibody Formation - genetics Antigens Biological & chemical terrorism Biomedical and Life Sciences Biomedicine Cancer Research Chemokines Clinical trials Cytokines DQA1 protein Drb1 protein Drug dosages Epidemiology Female Gene Expression Gene Frequency Genes Genetic diversity Genetic Variation Genotype Haplotypes Histocompatibility antigen HLA Histocompatibility Antigens Class I - genetics HLA-DQ Antigens - genetics HLA-DR Antigens - genetics Human Genetics Humans Immune response Immunoglobulin G Immunoglobulin G - biosynthesis Immunoglobulin G - genetics Immunology Infections Leukocytes Male Middle Aged Military personnel original-article Polymorphism, Single Nucleotide Protective antigen Public health Vaccines
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