Assessment of the safety and biodistribution of a regulated AAV2 gene transfer vector after delivery to murine submandibular glands

Clinical gene transfer holds promise for the treatment of many inherited and acquired disorders. A key consideration for all clinical gene transfer applications is the tight control of transgene expression. We have examined the safety and biodistribution of a serotype 2, recombinant adeno-associated...

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Veröffentlicht in:	Toxicological sciences 2011-09, Vol.123 (1), p.247-255
Hauptverfasser:	Zheng, Changyu, Voutetakis, Antonis, Goldstein, Benjamin, Afione, Sandra, Rivera, Victor M, Clackson, Tim, Wenk, Martin L, Boyle, Molly, Nyska, Abraham, Chiorini, John A, Vallant, Molly, Irwin, Richard D, Baum, Bruce J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Body Weight Dependovirus - genetics Erythropoietin - blood Erythropoietin - genetics Female Gene Transfer Techniques - adverse effects Genetic Vectors - administration & dosage Male Mice Mice, Inbred BALB C Risk Assessment Sex Factors Sirolimus - pharmacology Submandibular Gland - metabolism Submandibular Gland - virology Toxicity Tests
Online-Zugang:	Volltext
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