Differential Association of Docosahexaenoic and Eicosapentaenoic Acids With Carotid Intima-Media Thickness
Recent studies reported the differential effect of docosahexaenoic (DHA) and eicosapentaenoic acids (EPA). We examined the differential association of DHA and EPA with carotid intima-media thickness (IMT) in Japanese individuals in Japan and in U.S. white individuals and explored whether DHA or EPA...
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| Veröffentlicht in: | Stroke (1970) 2011-09, Vol.42 (9), p.2538-2543 |
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| creator | SEKIKAWA, Akira KADOWAKI, Takashi NAKATA, Katsumi KADOTA, Aya OTAKE, Terou MIURA, Katsuyuki CHOO, Jina ABBOTT, Robert D KULLER, Lewis H DAVID CURB, J UESHIMA, Hirotsugu EL-SAED, Aiman OKAMURA, Tomonori SUTTON-TYRRELL, Kim NAKAMURA, Yasuyuki EVANS, Rhobert W MITSUNAMI, Ken-Ichi EDMUNDOWICZ, Daniel NISHIO, Yoshihiko |
| description | Recent studies reported the differential effect of docosahexaenoic (DHA) and eicosapentaenoic acids (EPA). We examined the differential association of DHA and EPA with carotid intima-media thickness (IMT) in Japanese individuals in Japan and in U.S. white individuals and explored whether DHA or EPA contributes to the difference in IMT between the two groups.
A population-based cross-sectional study in 608 Japanese and U.S. white men aged 40 to 49 was conducted to assess IMT, serum DHA, EPA, and other cardiovascular risk factors.
Japanese compared to U.S. whites had significantly lower IMT (mean±SD, 618±81 and 672±94 μm for Japanese and whites, respectively; P2-fold higher levels of DHA and EPA. DHA, but not EPA, had an inverse association with IMT in both Japanese and U.S. whites. The inverse association remained only in Japanese men after adjusting for risk and other factors. The significant difference in multivariable-adjusted IMT became nonsignificant after further adjusting for DHA (mean difference, 17 μm; 95% CI, -8 to 43; P=0.177) but not EPA. In this multivariable-adjusted model, DHA but not EPA was a significant predictor of IMT (P=-0.032 versus 0.863, respectively).
These data suggest that DHA may have a more potent antiatherogenic effect than EPA, especially in levels observed in the Japanese, independent of risk factors. |
| doi_str_mv | 10.1161/STROKEAHA.110.613042 |
| format | Article |
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A population-based cross-sectional study in 608 Japanese and U.S. white men aged 40 to 49 was conducted to assess IMT, serum DHA, EPA, and other cardiovascular risk factors.
Japanese compared to U.S. whites had significantly lower IMT (mean±SD, 618±81 and 672±94 μm for Japanese and whites, respectively; P<0.001) and had >2-fold higher levels of DHA and EPA. DHA, but not EPA, had an inverse association with IMT in both Japanese and U.S. whites. The inverse association remained only in Japanese men after adjusting for risk and other factors. The significant difference in multivariable-adjusted IMT became nonsignificant after further adjusting for DHA (mean difference, 17 μm; 95% CI, -8 to 43; P=0.177) but not EPA. In this multivariable-adjusted model, DHA but not EPA was a significant predictor of IMT (P=-0.032 versus 0.863, respectively).
These data suggest that DHA may have a more potent antiatherogenic effect than EPA, especially in levels observed in the Japanese, independent of risk factors.</description><identifier>ISSN: 0039-2499</identifier><identifier>EISSN: 1524-4628</identifier><identifier>DOI: 10.1161/STROKEAHA.110.613042</identifier><identifier>PMID: 21757663</identifier><identifier>CODEN: SJCCA7</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; Asian Continental Ancestry Group ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Carotid Arteries - metabolism ; Carotid Arteries - pathology ; Carotid Artery Diseases - blood ; Carotid Artery Diseases - epidemiology ; Carotid Artery Diseases - pathology ; Cohort Studies ; Docosahexaenoic Acids - blood ; Eicosapentaenoic Acid - blood ; European Continental Ancestry Group ; Humans ; Japan - epidemiology ; Male ; Medical sciences ; Middle Aged ; Neurology ; Pennsylvania ; Risk Factors ; Tunica Intima - metabolism ; Tunica Intima - pathology ; Tunica Media - metabolism ; Tunica Media - pathology ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Stroke (1970), 2011-09, Vol.42 (9), p.2538-2543</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-432e642e5e04c73a3d9a3e62f28a97699e84e544517c45529762cb74b7f84f833</citedby><cites>FETCH-LOGICAL-c405t-432e642e5e04c73a3d9a3e62f28a97699e84e544517c45529762cb74b7f84f833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,3685,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24504653$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21757663$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SEKIKAWA, Akira</creatorcontrib><creatorcontrib>KADOWAKI, Takashi</creatorcontrib><creatorcontrib>NAKATA, Katsumi</creatorcontrib><creatorcontrib>KADOTA, Aya</creatorcontrib><creatorcontrib>OTAKE, Terou</creatorcontrib><creatorcontrib>MIURA, Katsuyuki</creatorcontrib><creatorcontrib>CHOO, Jina</creatorcontrib><creatorcontrib>ABBOTT, Robert D</creatorcontrib><creatorcontrib>KULLER, Lewis H</creatorcontrib><creatorcontrib>DAVID CURB, J</creatorcontrib><creatorcontrib>UESHIMA, Hirotsugu</creatorcontrib><creatorcontrib>EL-SAED, Aiman</creatorcontrib><creatorcontrib>OKAMURA, Tomonori</creatorcontrib><creatorcontrib>SUTTON-TYRRELL, Kim</creatorcontrib><creatorcontrib>NAKAMURA, Yasuyuki</creatorcontrib><creatorcontrib>EVANS, Rhobert W</creatorcontrib><creatorcontrib>MITSUNAMI, Ken-Ichi</creatorcontrib><creatorcontrib>EDMUNDOWICZ, Daniel</creatorcontrib><creatorcontrib>NISHIO, Yoshihiko</creatorcontrib><creatorcontrib>ERA JUMP Study group</creatorcontrib><creatorcontrib>for the ERA JUMP Study group</creatorcontrib><title>Differential Association of Docosahexaenoic and Eicosapentaenoic Acids With Carotid Intima-Media Thickness</title><title>Stroke (1970)</title><addtitle>Stroke</addtitle><description>Recent studies reported the differential effect of docosahexaenoic (DHA) and eicosapentaenoic acids (EPA). We examined the differential association of DHA and EPA with carotid intima-media thickness (IMT) in Japanese individuals in Japan and in U.S. white individuals and explored whether DHA or EPA contributes to the difference in IMT between the two groups.
A population-based cross-sectional study in 608 Japanese and U.S. white men aged 40 to 49 was conducted to assess IMT, serum DHA, EPA, and other cardiovascular risk factors.
Japanese compared to U.S. whites had significantly lower IMT (mean±SD, 618±81 and 672±94 μm for Japanese and whites, respectively; P<0.001) and had >2-fold higher levels of DHA and EPA. DHA, but not EPA, had an inverse association with IMT in both Japanese and U.S. whites. The inverse association remained only in Japanese men after adjusting for risk and other factors. The significant difference in multivariable-adjusted IMT became nonsignificant after further adjusting for DHA (mean difference, 17 μm; 95% CI, -8 to 43; P=0.177) but not EPA. In this multivariable-adjusted model, DHA but not EPA was a significant predictor of IMT (P=-0.032 versus 0.863, respectively).
These data suggest that DHA may have a more potent antiatherogenic effect than EPA, especially in levels observed in the Japanese, independent of risk factors.</description><subject>Adult</subject><subject>Asian Continental Ancestry Group</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Carotid Arteries - metabolism</subject><subject>Carotid Arteries - pathology</subject><subject>Carotid Artery Diseases - blood</subject><subject>Carotid Artery Diseases - epidemiology</subject><subject>Carotid Artery Diseases - pathology</subject><subject>Cohort Studies</subject><subject>Docosahexaenoic Acids - blood</subject><subject>Eicosapentaenoic Acid - blood</subject><subject>European Continental Ancestry Group</subject><subject>Humans</subject><subject>Japan - epidemiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Pennsylvania</subject><subject>Risk Factors</subject><subject>Tunica Intima - metabolism</subject><subject>Tunica Intima - pathology</subject><subject>Tunica Media - metabolism</subject><subject>Tunica Media - pathology</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0039-2499</issn><issn>1524-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUMlOwzAQtRAIyvIHCPnCMeBl7CQXpKiURYCQoIhjNHVsaihxFQcEf49RS4HTaN68ZfQI2efsiHPNj-_Hd7dXo-qiSis70lwyEGtkwJWADLQo1smAMVlmAspyi2zH-MwYE7JQm2RL8FzlWssBeT71ztnOtr3HGa1iDMZj70NLg6OnwYSIU_uBtg3eUGwbOvLf2DwJlmBlfBPpo--ndIhd6H1DL5PbK2Y3tvFIx1NvXlob4y7ZcDiLdm85d8jD2Wg8vMiub88vh9V1ZoCpPgMprAZhlWVgcomyKVFaLZwosMx1WdoCrAJQPDeglEiYMJMcJrkrwBVS7pCThe_8bfJqG5Ne7XBWz7v0U_dZB_T1_0vrp_VTeK8lT7lSJwNYGJguxNhZt9JyVn93X6-6TyurF90n2cHf3JXop-xEOFwSMBqcuQ5b4-MvDxQDraT8AifVj0M</recordid><startdate>20110901</startdate><enddate>20110901</enddate><creator>SEKIKAWA, Akira</creator><creator>KADOWAKI, Takashi</creator><creator>NAKATA, Katsumi</creator><creator>KADOTA, Aya</creator><creator>OTAKE, Terou</creator><creator>MIURA, Katsuyuki</creator><creator>CHOO, Jina</creator><creator>ABBOTT, Robert D</creator><creator>KULLER, Lewis H</creator><creator>DAVID CURB, J</creator><creator>UESHIMA, Hirotsugu</creator><creator>EL-SAED, Aiman</creator><creator>OKAMURA, Tomonori</creator><creator>SUTTON-TYRRELL, Kim</creator><creator>NAKAMURA, Yasuyuki</creator><creator>EVANS, Rhobert W</creator><creator>MITSUNAMI, Ken-Ichi</creator><creator>EDMUNDOWICZ, Daniel</creator><creator>NISHIO, Yoshihiko</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20110901</creationdate><title>Differential Association of Docosahexaenoic and Eicosapentaenoic Acids With Carotid Intima-Media Thickness</title><author>SEKIKAWA, Akira ; KADOWAKI, Takashi ; NAKATA, Katsumi ; KADOTA, Aya ; OTAKE, Terou ; MIURA, Katsuyuki ; CHOO, Jina ; ABBOTT, Robert D ; KULLER, Lewis H ; DAVID CURB, J ; UESHIMA, Hirotsugu ; EL-SAED, Aiman ; OKAMURA, Tomonori ; SUTTON-TYRRELL, Kim ; NAKAMURA, Yasuyuki ; EVANS, Rhobert W ; MITSUNAMI, Ken-Ichi ; EDMUNDOWICZ, Daniel ; NISHIO, Yoshihiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-432e642e5e04c73a3d9a3e62f28a97699e84e544517c45529762cb74b7f84f833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Asian Continental Ancestry Group</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Carotid Arteries - metabolism</topic><topic>Carotid Arteries - pathology</topic><topic>Carotid Artery Diseases - blood</topic><topic>Carotid Artery Diseases - epidemiology</topic><topic>Carotid Artery Diseases - pathology</topic><topic>Cohort Studies</topic><topic>Docosahexaenoic Acids - blood</topic><topic>Eicosapentaenoic Acid - blood</topic><topic>European Continental Ancestry Group</topic><topic>Humans</topic><topic>Japan - epidemiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Pennsylvania</topic><topic>Risk Factors</topic><topic>Tunica Intima - metabolism</topic><topic>Tunica Intima - pathology</topic><topic>Tunica Media - metabolism</topic><topic>Tunica Media - pathology</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SEKIKAWA, Akira</creatorcontrib><creatorcontrib>KADOWAKI, Takashi</creatorcontrib><creatorcontrib>NAKATA, Katsumi</creatorcontrib><creatorcontrib>KADOTA, Aya</creatorcontrib><creatorcontrib>OTAKE, Terou</creatorcontrib><creatorcontrib>MIURA, Katsuyuki</creatorcontrib><creatorcontrib>CHOO, Jina</creatorcontrib><creatorcontrib>ABBOTT, Robert D</creatorcontrib><creatorcontrib>KULLER, Lewis H</creatorcontrib><creatorcontrib>DAVID CURB, J</creatorcontrib><creatorcontrib>UESHIMA, Hirotsugu</creatorcontrib><creatorcontrib>EL-SAED, Aiman</creatorcontrib><creatorcontrib>OKAMURA, Tomonori</creatorcontrib><creatorcontrib>SUTTON-TYRRELL, Kim</creatorcontrib><creatorcontrib>NAKAMURA, Yasuyuki</creatorcontrib><creatorcontrib>EVANS, Rhobert W</creatorcontrib><creatorcontrib>MITSUNAMI, Ken-Ichi</creatorcontrib><creatorcontrib>EDMUNDOWICZ, Daniel</creatorcontrib><creatorcontrib>NISHIO, Yoshihiko</creatorcontrib><creatorcontrib>ERA JUMP Study group</creatorcontrib><creatorcontrib>for the ERA JUMP Study group</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Stroke (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SEKIKAWA, Akira</au><au>KADOWAKI, Takashi</au><au>NAKATA, Katsumi</au><au>KADOTA, Aya</au><au>OTAKE, Terou</au><au>MIURA, Katsuyuki</au><au>CHOO, Jina</au><au>ABBOTT, Robert D</au><au>KULLER, Lewis H</au><au>DAVID CURB, J</au><au>UESHIMA, Hirotsugu</au><au>EL-SAED, Aiman</au><au>OKAMURA, Tomonori</au><au>SUTTON-TYRRELL, Kim</au><au>NAKAMURA, Yasuyuki</au><au>EVANS, Rhobert W</au><au>MITSUNAMI, Ken-Ichi</au><au>EDMUNDOWICZ, Daniel</au><au>NISHIO, Yoshihiko</au><aucorp>ERA JUMP Study group</aucorp><aucorp>for the ERA JUMP Study group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential Association of Docosahexaenoic and Eicosapentaenoic Acids With Carotid Intima-Media Thickness</atitle><jtitle>Stroke (1970)</jtitle><addtitle>Stroke</addtitle><date>2011-09-01</date><risdate>2011</risdate><volume>42</volume><issue>9</issue><spage>2538</spage><epage>2543</epage><pages>2538-2543</pages><issn>0039-2499</issn><eissn>1524-4628</eissn><coden>SJCCA7</coden><abstract>Recent studies reported the differential effect of docosahexaenoic (DHA) and eicosapentaenoic acids (EPA). We examined the differential association of DHA and EPA with carotid intima-media thickness (IMT) in Japanese individuals in Japan and in U.S. white individuals and explored whether DHA or EPA contributes to the difference in IMT between the two groups.
A population-based cross-sectional study in 608 Japanese and U.S. white men aged 40 to 49 was conducted to assess IMT, serum DHA, EPA, and other cardiovascular risk factors.
Japanese compared to U.S. whites had significantly lower IMT (mean±SD, 618±81 and 672±94 μm for Japanese and whites, respectively; P<0.001) and had >2-fold higher levels of DHA and EPA. DHA, but not EPA, had an inverse association with IMT in both Japanese and U.S. whites. The inverse association remained only in Japanese men after adjusting for risk and other factors. The significant difference in multivariable-adjusted IMT became nonsignificant after further adjusting for DHA (mean difference, 17 μm; 95% CI, -8 to 43; P=0.177) but not EPA. In this multivariable-adjusted model, DHA but not EPA was a significant predictor of IMT (P=-0.032 versus 0.863, respectively).
These data suggest that DHA may have a more potent antiatherogenic effect than EPA, especially in levels observed in the Japanese, independent of risk factors.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>21757663</pmid><doi>10.1161/STROKEAHA.110.613042</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0039-2499 |
| ispartof | Stroke (1970), 2011-09, Vol.42 (9), p.2538-2543 |
| issn | 0039-2499 1524-4628 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3164236 |
| source | MEDLINE; American Heart Association Journals; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Asian Continental Ancestry Group Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Carotid Arteries - metabolism Carotid Arteries - pathology Carotid Artery Diseases - blood Carotid Artery Diseases - epidemiology Carotid Artery Diseases - pathology Cohort Studies Docosahexaenoic Acids - blood Eicosapentaenoic Acid - blood European Continental Ancestry Group Humans Japan - epidemiology Male Medical sciences Middle Aged Neurology Pennsylvania Risk Factors Tunica Intima - metabolism Tunica Intima - pathology Tunica Media - metabolism Tunica Media - pathology Vascular diseases and vascular malformations of the nervous system |
| title | Differential Association of Docosahexaenoic and Eicosapentaenoic Acids With Carotid Intima-Media Thickness |
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