Epidemiology of generalized joint laxity (hypermobility) in fourteen‐year‐old children from the UK: A population‐based evaluation
Objective Although diagnostic criteria for generalized ligamentous laxity (hypermobility) in children are widely used, their validity may be limited, due to the lack of robust descriptive epidemiologic data on this condition. The present study was undertaken to describe the point prevalence and patt...
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| Veröffentlicht in: | Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2011-09, Vol.63 (9), p.2819-2827 |
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| creator | Clinch, Jacqui Deere, Kevin Sayers, Adrian Palmer, Shea Riddoch, Chris Tobias, Jonathan H. Clark, Emma M. |
| description | Objective
Although diagnostic criteria for generalized ligamentous laxity (hypermobility) in children are widely used, their validity may be limited, due to the lack of robust descriptive epidemiologic data on this condition. The present study was undertaken to describe the point prevalence and pattern of hypermobility in 14‐year‐old children from a population‐based cohort.
Methods
We performed a cross‐sectional analysis using the Avon Longitudinal Study of Parents and Children, a large population‐based birth cohort. Hypermobility among children in the cohort (mean age 13.8 years) was measured using the Beighton scoring system. Objective measures of physical activity were ascertained by accelerometry. Data on other variables, including puberty and socioeconomic status, were collected. Simple prevalence rates were calculated. Chi‐square tests and logistic regression analyses were used to assess associations of specific variables with hypermobility.
Results
Among the 6,022 children evaluated, the prevalence of hypermobility (defined as a Beighton score of ≥4 [i.e., ≥4 joints affected]) in girls and boys age 13.8 years was 27.5% and 10.6%, respectively. Forty‐five percent of girls and 29% of boys had hypermobile fingers. There was a suggestion of a positive association between hypermobility in girls and variables including physical activity, body mass index, and maternal education. No associations were seen in boys.
Conclusion
We have shown that the prevalence of hypermobility in UK children is high, possibly suggesting that the Beighton score cutoff of ≥4 is too low or that this scoring is not appropriate for use in subjects whose musculoskeletal system is still developing. These results provide a platform to evaluate the relationships between the Beighton criteria and key clinical features (including pain), thereby testing the clinical validity of this scoring system in the pediatric population. |
| doi_str_mv | 10.1002/art.30435 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3164233</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>888089932</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5385-ab81733d7fb554f7074c427ae1a54bfd00905d6f4ff3c5fab4d1bf22f5eee66d3</originalsourceid><addsrcrecordid>eNp1kc9u1DAQxi1ERZfCgRdAlhCCHtLasb1JOCCtqtIiKiGh9mw58XjXKydO7aQQTty48ow8Sb3dpfyROI3G89P3zfhD6BklR5SQ_FiF4YgRzsQDNKMirzJCGX2IZoQQnjFR0X30OMZ1anMm2CO0n1PBi7LiM_T9tLcaWuudX07YG7yEDoJy9itovPa2G7BTX-ww4derqYfQ-tq61B5i22HjxzAAdD-__ZhAhVS807hZWacDpHHwLR5WgK8-vMEL3Pt-dGqwfsPXKiYDuFFuvHt6gvaMchGe7uoBunp3enlynl18PHt_srjIGsFKkam6pAVjujC1ENwUpOANzwsFVAleG01IRYSeG24Ma4RRNde0NnluBADM55odoLdb3X6sW9ANdEO6VvbBtipM0isr_550diWX_kYyOuc5Y0ng1U4g-OsR4iBbGxtwTnXgxyjLsiRlVbE8kS_-Idfpv7p0naSCFpRWBSkTdbilmuBjDGDud6FEbtKVKV15l25in_-5_D35K84EvNwBKjbKmaC6xsbfHBc8WW-EjrfcZ-tg-r-jXHy63FrfAiY0whU</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1517119708</pqid></control><display><type>article</type><title>Epidemiology of generalized joint laxity (hypermobility) in fourteen‐year‐old children from the UK: A population‐based evaluation</title><source>MEDLINE</source><source>Wiley Journals</source><creator>Clinch, Jacqui ; Deere, Kevin ; Sayers, Adrian ; Palmer, Shea ; Riddoch, Chris ; Tobias, Jonathan H. ; Clark, Emma M.</creator><creatorcontrib>Clinch, Jacqui ; Deere, Kevin ; Sayers, Adrian ; Palmer, Shea ; Riddoch, Chris ; Tobias, Jonathan H. ; Clark, Emma M.</creatorcontrib><description>Objective
Although diagnostic criteria for generalized ligamentous laxity (hypermobility) in children are widely used, their validity may be limited, due to the lack of robust descriptive epidemiologic data on this condition. The present study was undertaken to describe the point prevalence and pattern of hypermobility in 14‐year‐old children from a population‐based cohort.
Methods
We performed a cross‐sectional analysis using the Avon Longitudinal Study of Parents and Children, a large population‐based birth cohort. Hypermobility among children in the cohort (mean age 13.8 years) was measured using the Beighton scoring system. Objective measures of physical activity were ascertained by accelerometry. Data on other variables, including puberty and socioeconomic status, were collected. Simple prevalence rates were calculated. Chi‐square tests and logistic regression analyses were used to assess associations of specific variables with hypermobility.
Results
Among the 6,022 children evaluated, the prevalence of hypermobility (defined as a Beighton score of ≥4 [i.e., ≥4 joints affected]) in girls and boys age 13.8 years was 27.5% and 10.6%, respectively. Forty‐five percent of girls and 29% of boys had hypermobile fingers. There was a suggestion of a positive association between hypermobility in girls and variables including physical activity, body mass index, and maternal education. No associations were seen in boys.
Conclusion
We have shown that the prevalence of hypermobility in UK children is high, possibly suggesting that the Beighton score cutoff of ≥4 is too low or that this scoring is not appropriate for use in subjects whose musculoskeletal system is still developing. These results provide a platform to evaluate the relationships between the Beighton criteria and key clinical features (including pain), thereby testing the clinical validity of this scoring system in the pediatric population.</description><identifier>ISSN: 0004-3591</identifier><identifier>ISSN: 2326-5191</identifier><identifier>EISSN: 1529-0131</identifier><identifier>EISSN: 2326-5205</identifier><identifier>DOI: 10.1002/art.30435</identifier><identifier>PMID: 21547894</identifier><identifier>CODEN: ARHEAW</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; Biological and medical sciences ; Children & youth ; Cohort Studies ; Cross-Sectional Studies ; Diseases of the osteoarticular system ; Female ; Humans ; Joint Instability - diagnosis ; Joint Instability - epidemiology ; Joint Instability - physiopathology ; Joints - physiopathology ; Male ; Medical sciences ; Pediatric Rheumatology ; Population ; Prevalence ; United Kingdom - epidemiology</subject><ispartof>Arthritis & rheumatology (Hoboken, N.J.), 2011-09, Vol.63 (9), p.2819-2827</ispartof><rights>Copyright © 2011 by the American College of Rheumatology</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 by the American College of Rheumatology.</rights><rights>Copyright © 2011 by the American College of Rheumatology 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5385-ab81733d7fb554f7074c427ae1a54bfd00905d6f4ff3c5fab4d1bf22f5eee66d3</citedby><cites>FETCH-LOGICAL-c5385-ab81733d7fb554f7074c427ae1a54bfd00905d6f4ff3c5fab4d1bf22f5eee66d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fart.30435$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fart.30435$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24541515$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21547894$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Clinch, Jacqui</creatorcontrib><creatorcontrib>Deere, Kevin</creatorcontrib><creatorcontrib>Sayers, Adrian</creatorcontrib><creatorcontrib>Palmer, Shea</creatorcontrib><creatorcontrib>Riddoch, Chris</creatorcontrib><creatorcontrib>Tobias, Jonathan H.</creatorcontrib><creatorcontrib>Clark, Emma M.</creatorcontrib><title>Epidemiology of generalized joint laxity (hypermobility) in fourteen‐year‐old children from the UK: A population‐based evaluation</title><title>Arthritis & rheumatology (Hoboken, N.J.)</title><addtitle>Arthritis Rheum</addtitle><description>Objective
Although diagnostic criteria for generalized ligamentous laxity (hypermobility) in children are widely used, their validity may be limited, due to the lack of robust descriptive epidemiologic data on this condition. The present study was undertaken to describe the point prevalence and pattern of hypermobility in 14‐year‐old children from a population‐based cohort.
Methods
We performed a cross‐sectional analysis using the Avon Longitudinal Study of Parents and Children, a large population‐based birth cohort. Hypermobility among children in the cohort (mean age 13.8 years) was measured using the Beighton scoring system. Objective measures of physical activity were ascertained by accelerometry. Data on other variables, including puberty and socioeconomic status, were collected. Simple prevalence rates were calculated. Chi‐square tests and logistic regression analyses were used to assess associations of specific variables with hypermobility.
Results
Among the 6,022 children evaluated, the prevalence of hypermobility (defined as a Beighton score of ≥4 [i.e., ≥4 joints affected]) in girls and boys age 13.8 years was 27.5% and 10.6%, respectively. Forty‐five percent of girls and 29% of boys had hypermobile fingers. There was a suggestion of a positive association between hypermobility in girls and variables including physical activity, body mass index, and maternal education. No associations were seen in boys.
Conclusion
We have shown that the prevalence of hypermobility in UK children is high, possibly suggesting that the Beighton score cutoff of ≥4 is too low or that this scoring is not appropriate for use in subjects whose musculoskeletal system is still developing. These results provide a platform to evaluate the relationships between the Beighton criteria and key clinical features (including pain), thereby testing the clinical validity of this scoring system in the pediatric population.</description><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Children & youth</subject><subject>Cohort Studies</subject><subject>Cross-Sectional Studies</subject><subject>Diseases of the osteoarticular system</subject><subject>Female</subject><subject>Humans</subject><subject>Joint Instability - diagnosis</subject><subject>Joint Instability - epidemiology</subject><subject>Joint Instability - physiopathology</subject><subject>Joints - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pediatric Rheumatology</subject><subject>Population</subject><subject>Prevalence</subject><subject>United Kingdom - epidemiology</subject><issn>0004-3591</issn><issn>2326-5191</issn><issn>1529-0131</issn><issn>2326-5205</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp1kc9u1DAQxi1ERZfCgRdAlhCCHtLasb1JOCCtqtIiKiGh9mw58XjXKydO7aQQTty48ow8Sb3dpfyROI3G89P3zfhD6BklR5SQ_FiF4YgRzsQDNKMirzJCGX2IZoQQnjFR0X30OMZ1anMm2CO0n1PBi7LiM_T9tLcaWuudX07YG7yEDoJy9itovPa2G7BTX-ww4derqYfQ-tq61B5i22HjxzAAdD-__ZhAhVS807hZWacDpHHwLR5WgK8-vMEL3Pt-dGqwfsPXKiYDuFFuvHt6gvaMchGe7uoBunp3enlynl18PHt_srjIGsFKkam6pAVjujC1ENwUpOANzwsFVAleG01IRYSeG24Ma4RRNde0NnluBADM55odoLdb3X6sW9ANdEO6VvbBtipM0isr_550diWX_kYyOuc5Y0ng1U4g-OsR4iBbGxtwTnXgxyjLsiRlVbE8kS_-Idfpv7p0naSCFpRWBSkTdbilmuBjDGDud6FEbtKVKV15l25in_-5_D35K84EvNwBKjbKmaC6xsbfHBc8WW-EjrfcZ-tg-r-jXHy63FrfAiY0whU</recordid><startdate>201109</startdate><enddate>201109</enddate><creator>Clinch, Jacqui</creator><creator>Deere, Kevin</creator><creator>Sayers, Adrian</creator><creator>Palmer, Shea</creator><creator>Riddoch, Chris</creator><creator>Tobias, Jonathan H.</creator><creator>Clark, Emma M.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7T5</scope><scope>7TM</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201109</creationdate><title>Epidemiology of generalized joint laxity (hypermobility) in fourteen‐year‐old children from the UK: A population‐based evaluation</title><author>Clinch, Jacqui ; Deere, Kevin ; Sayers, Adrian ; Palmer, Shea ; Riddoch, Chris ; Tobias, Jonathan H. ; Clark, Emma M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5385-ab81733d7fb554f7074c427ae1a54bfd00905d6f4ff3c5fab4d1bf22f5eee66d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>Children & youth</topic><topic>Cohort Studies</topic><topic>Cross-Sectional Studies</topic><topic>Diseases of the osteoarticular system</topic><topic>Female</topic><topic>Humans</topic><topic>Joint Instability - diagnosis</topic><topic>Joint Instability - epidemiology</topic><topic>Joint Instability - physiopathology</topic><topic>Joints - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pediatric Rheumatology</topic><topic>Population</topic><topic>Prevalence</topic><topic>United Kingdom - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Clinch, Jacqui</creatorcontrib><creatorcontrib>Deere, Kevin</creatorcontrib><creatorcontrib>Sayers, Adrian</creatorcontrib><creatorcontrib>Palmer, Shea</creatorcontrib><creatorcontrib>Riddoch, Chris</creatorcontrib><creatorcontrib>Tobias, Jonathan H.</creatorcontrib><creatorcontrib>Clark, Emma M.</creatorcontrib><collection>Wiley Online Library (Open Access Collection)</collection><collection>Wiley Online Library (Open Access Collection)</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Arthritis & rheumatology (Hoboken, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Clinch, Jacqui</au><au>Deere, Kevin</au><au>Sayers, Adrian</au><au>Palmer, Shea</au><au>Riddoch, Chris</au><au>Tobias, Jonathan H.</au><au>Clark, Emma M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epidemiology of generalized joint laxity (hypermobility) in fourteen‐year‐old children from the UK: A population‐based evaluation</atitle><jtitle>Arthritis & rheumatology (Hoboken, N.J.)</jtitle><addtitle>Arthritis Rheum</addtitle><date>2011-09</date><risdate>2011</risdate><volume>63</volume><issue>9</issue><spage>2819</spage><epage>2827</epage><pages>2819-2827</pages><issn>0004-3591</issn><issn>2326-5191</issn><eissn>1529-0131</eissn><eissn>2326-5205</eissn><coden>ARHEAW</coden><abstract>Objective
Although diagnostic criteria for generalized ligamentous laxity (hypermobility) in children are widely used, their validity may be limited, due to the lack of robust descriptive epidemiologic data on this condition. The present study was undertaken to describe the point prevalence and pattern of hypermobility in 14‐year‐old children from a population‐based cohort.
Methods
We performed a cross‐sectional analysis using the Avon Longitudinal Study of Parents and Children, a large population‐based birth cohort. Hypermobility among children in the cohort (mean age 13.8 years) was measured using the Beighton scoring system. Objective measures of physical activity were ascertained by accelerometry. Data on other variables, including puberty and socioeconomic status, were collected. Simple prevalence rates were calculated. Chi‐square tests and logistic regression analyses were used to assess associations of specific variables with hypermobility.
Results
Among the 6,022 children evaluated, the prevalence of hypermobility (defined as a Beighton score of ≥4 [i.e., ≥4 joints affected]) in girls and boys age 13.8 years was 27.5% and 10.6%, respectively. Forty‐five percent of girls and 29% of boys had hypermobile fingers. There was a suggestion of a positive association between hypermobility in girls and variables including physical activity, body mass index, and maternal education. No associations were seen in boys.
Conclusion
We have shown that the prevalence of hypermobility in UK children is high, possibly suggesting that the Beighton score cutoff of ≥4 is too low or that this scoring is not appropriate for use in subjects whose musculoskeletal system is still developing. These results provide a platform to evaluate the relationships between the Beighton criteria and key clinical features (including pain), thereby testing the clinical validity of this scoring system in the pediatric population.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>21547894</pmid><doi>10.1002/art.30435</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Arthritis & rheumatology (Hoboken, N.J.), 2011-09, Vol.63 (9), p.2819-2827 |
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| source | MEDLINE; Wiley Journals |
| subjects | Adolescent Biological and medical sciences Children & youth Cohort Studies Cross-Sectional Studies Diseases of the osteoarticular system Female Humans Joint Instability - diagnosis Joint Instability - epidemiology Joint Instability - physiopathology Joints - physiopathology Male Medical sciences Pediatric Rheumatology Population Prevalence United Kingdom - epidemiology |
| title | Epidemiology of generalized joint laxity (hypermobility) in fourteen‐year‐old children from the UK: A population‐based evaluation |
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