Progesterone blocks multiple routes of ion flux

The administration of progesterone as a neuroprotective agent following traumatic brain injury has recently entered phase III clinical trials. Previous work has demonstrated that therapeutic concentrations of progesterone decrease excitotoxicity through direct inhibition of voltage-gated calcium cha...

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Veröffentlicht in:	Molecular and cellular neuroscience 2011-10, Vol.48 (2), p.137-141
Hauptverfasser:	Kelley, Brooke G., Mermelstein, Paul G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Corpus Striatum - cytology Female Ion Channel Gating - drug effects Ions - metabolism Male Membrane Potentials - drug effects Neurons - cytology Neurons - drug effects Neurons - physiology Neuroprotection Patch-Clamp Techniques Potassium Channels, Voltage-Gated - metabolism Progesterone - pharmacology Rats Rats, Sprague-Dawley Side effects Steroid Striatum Traumatic brain injury
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