Identification of a novel mechanism of regulation of Ah (dioxin) receptor function
Ah receptor (AhR) is a ligand-activated transcription factor that mediates pleiotropic effects of environmental pollutants such as 2,3, 7,8-tetrachlorodibenzo-p-dioxin on host animals. In addition to induction of drug-metabolizing enzymes, the liganded AhR complex was found to activate gene expressi...
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| Veröffentlicht in: | Genes & development 1999-01, Vol.13 (1), p.20-25 |
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| container_title | Genes & development |
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| creator | Mimura, J Ema, M Sogawa, K Fujii-Kuriyama, Y |
| description | Ah receptor (AhR) is a ligand-activated transcription factor that mediates pleiotropic effects of environmental pollutants such as 2,3, 7,8-tetrachlorodibenzo-p-dioxin on host animals. In addition to induction of drug-metabolizing enzymes, the liganded AhR complex was found to activate gene expression of a factor designated AhR repressor (AhRR), which inhibits AhR function by competing with AhR for dimerizing with Arnt and binding to the XRE sequence. Thus, AhR and AhRR form a regulatory circuit in the xenobiotic signal transduction pathway and provide a novel mechanism of regulation of AhR function that may determine tissue-specific sensitivity to environmental pollutants. |
| doi_str_mv | 10.1101/gad.13.1.20 |
| format | Article |
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In addition to induction of drug-metabolizing enzymes, the liganded AhR complex was found to activate gene expression of a factor designated AhR repressor (AhRR), which inhibits AhR function by competing with AhR for dimerizing with Arnt and binding to the XRE sequence. 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Thus, AhR and AhRR form a regulatory circuit in the xenobiotic signal transduction pathway and provide a novel mechanism of regulation of AhR function that may determine tissue-specific sensitivity to environmental pollutants.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Aryl Hydrocarbon Receptor Nuclear Translocator</subject><subject>Basic Helix-Loop-Helix Transcription Factors</subject><subject>Cloning, Molecular</subject><subject>Dimerization</subject><subject>DNA-Binding Proteins</subject><subject>Gene Expression Regulation - genetics</subject><subject>Helix-Loop-Helix Motifs - genetics</subject><subject>Mice</subject><subject>Molecular Sequence Data</subject><subject>Polychlorinated Dibenzodioxins - metabolism</subject><subject>Promoter Regions, Genetic - genetics</subject><subject>Protein Binding - genetics</subject><subject>Receptors, Aryl Hydrocarbon - metabolism</subject><subject>Recombinant Fusion Proteins - genetics</subject><subject>Repressor Proteins - chemistry</subject><subject>Repressor Proteins - genetics</subject><subject>Research Communication</subject><subject>Sequence Analysis, DNA</subject><subject>Sequence Homology, Amino Acid</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><subject>Transcriptional Activation - genetics</subject><issn>0890-9369</issn><issn>1549-5477</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtLw0AUhQdRan2sXAtZiSKJczPJPBYuSvFRKAii62EymWlHkkzNJEX_vSktRVeuLtz7ncO5HIQuACcAGO4WqkyAJJCk-ACNIc9EnGeMHaIx5gLHglBxjE5C-MAYU0zpCI0E5wwLOkavs9I0nbNOq875JvI2UlHj16aKaqOXqnGh3ixbs-irPTJZRtel81-uuRku2qw630a2b_QGOENHVlXBnO_mKXp_fHibPsfzl6fZdDKPdcbSLqaCA-WgiBBcU8O1AZ7bghap5tSwFOOiyApBBnumubZlaVNdFHlaKrA8L8kput_6rvqiNqUe_mhVJVetq1X7Lb1y8u-lcUu58GtJgBIGg_5qp2_9Z29CJ2sXtKkq1RjfB0lFnudUZP-CwCBjnJIBvN2CuvUhtMbuwwCWm6rkUJUEIkGmeKAvf-ffs7tuyA8eApF_</recordid><startdate>19990101</startdate><enddate>19990101</enddate><creator>Mimura, J</creator><creator>Ema, M</creator><creator>Sogawa, K</creator><creator>Fujii-Kuriyama, Y</creator><general>Cold Spring Harbor Laboratory Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19990101</creationdate><title>Identification of a novel mechanism of regulation of Ah (dioxin) receptor function</title><author>Mimura, J ; 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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Amino Acid Sequence Animals Aryl Hydrocarbon Receptor Nuclear Translocator Basic Helix-Loop-Helix Transcription Factors Cloning, Molecular Dimerization DNA-Binding Proteins Gene Expression Regulation - genetics Helix-Loop-Helix Motifs - genetics Mice Molecular Sequence Data Polychlorinated Dibenzodioxins - metabolism Promoter Regions, Genetic - genetics Protein Binding - genetics Receptors, Aryl Hydrocarbon - metabolism Recombinant Fusion Proteins - genetics Repressor Proteins - chemistry Repressor Proteins - genetics Research Communication Sequence Analysis, DNA Sequence Homology, Amino Acid Transcription Factors - genetics Transcription Factors - metabolism Transcriptional Activation - genetics |
| title | Identification of a novel mechanism of regulation of Ah (dioxin) receptor function |
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