Targeted Vault Nanoparticles Engineered with an Endosomolytic Peptide Deliver Biomolecules to the Cytoplasm

Vault nanoparticles were engineered to enhance their escape from the endosomal compartment by fusing a membrane lytic peptide derived from adenovirus protein VI (pVI) to the N-terminus of the major vault protein to form pVI-vaults. We demonstrate that these pVI-vaults disrupt the endosomal membrane...

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Veröffentlicht in:	ACS nano 2011-08, Vol.5 (8), p.6128-6137
Hauptverfasser:	Han, Muri, Kickhoefer, Valerie A, Nemerow, Glen R, Rome, Leonard H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Transport Biomolecules Calcium Phosphates - metabolism Compartments Cytoplasm Cytoplasm - metabolism Cytosol - metabolism DNA - genetics DNA - metabolism Endosomes - metabolism Engineering - methods Fluorescence HeLa Cells Humans Intracellular Membranes - metabolism Luciferases - genetics Macrophages - metabolism Membranes Mice Nanoparticles Nanoparticles - chemistry Nanotechnology - methods Peptide Fragments - metabolism Peptides Proteins Receptor, Epidermal Growth Factor - metabolism Substrate Specificity Transfection Vault Ribonucleoprotein Particles - chemistry Vault Ribonucleoprotein Particles - metabolism Vaults Viral Proteins - metabolism
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